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Thrb thyroid hormone receptor beta [ Mus musculus (house mouse) ]

Gene ID: 21834, updated on 17-Jan-2023

Summary

Official Symbol
Thrbprovided by MGI
Official Full Name
thyroid hormone receptor betaprovided by MGI
Primary source
MGI:MGI:98743
See related
Ensembl:ENSMUSG00000021779 AllianceGenome:MGI:98743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta
Summary
Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; thyroid gland follicular carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 2.1), adrenal adult (RPKM 2.1) and 24 other tissues See more
Orthologs
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Genomic context

See Thrb in Genome Data Viewer
Location:
14; 14 A1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4429599..4810538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (17659225..18040097)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53217 Neighboring gene predicted gene, 32269 Neighboring gene predicted gene, 32187

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (17)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141269, MGC141270

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables thyroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female courtship behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of female receptivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of thyroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinal cone cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of retinal cone cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thyroid hormone mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within type I pneumocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
thyroid hormone receptor beta
Names
TR beta
c-erbA-2
c-erbA-beta
nuclear receptor subfamily 1 group A member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113417.1NP_001106888.1  thyroid hormone receptor beta isoform 1

    See identical proteins and their annotated locations for NP_001106888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR and multiple 5' coding region differences, compared to variant 2. Codons 1-94 of this variant are encoded by exons that are not present in variant 2. The encoded protein (isoform 1) is identical to isoform 2 in the C-terminus.
    Source sequence(s)
    AC154626, AC154681, AK133662, AK158826
    Consensus CDS
    CCDS49404.1
    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    UniProtKB/TrEMBL
    Q3UZT5
    Related
    ENSMUSP00000022303.10, ENSMUST00000022303.17
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  2. NM_009380.3NP_033406.1  thyroid hormone receptor beta isoform 2

    See identical proteins and their annotated locations for NP_033406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC154626, AC154681, BC089035
    Consensus CDS
    CCDS26835.1
    UniProtKB/Swiss-Prot
    P37242
    Related
    ENSMUSP00000022304.11, ENSMUST00000022304.12
    Conserved Domains (2) summary
    cd06935
    Location:230472
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:120206
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    4429599..4810538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158539.1XP_036014432.1  thyroid hormone receptor beta isoform X2

    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  2. XM_011244739.4XP_011243041.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011243041.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  3. XM_036158537.1XP_036014430.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  4. XM_011244741.4XP_011243043.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011243043.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  5. XM_011244743.4XP_011243045.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011243045.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  6. XM_011244740.4XP_011243042.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011243042.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  7. XM_006517972.5XP_006518035.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006518035.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  8. XM_006517971.5XP_006518034.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006518034.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  9. XM_006517970.5XP_006518033.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006518033.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  10. XM_030247721.2XP_030103581.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  11. XM_006517967.5XP_006518030.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006518030.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  12. XM_036158538.1XP_036014431.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  13. XM_006517968.5XP_006518031.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006518031.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  14. XM_006517966.4XP_006518029.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_006518029.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Related
    ENSMUSP00000089053.5, ENSMUST00000091471.12
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  15. XM_011244737.3XP_011243039.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011243039.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  16. XM_011244745.3XP_011243047.1  thyroid hormone receptor beta isoform X2

    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  17. XM_011244742.3XP_011243044.1  thyroid hormone receptor beta isoform X1

    See identical proteins and their annotated locations for XP_011243044.1

    UniProtKB/Swiss-Prot
    P37242, Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  18. XM_030247720.2XP_030103580.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  19. XM_036158536.1XP_036014429.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q3TY80
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers