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THOP1 thimet oligopeptidase 1 [ Homo sapiens (human) ]

Gene ID: 7064, updated on 9-Jan-2019

Summary

Official Symbol
THOP1provided by HGNC
Official Full Name
thimet oligopeptidase 1provided by HGNC
Primary source
HGNC:HGNC:11793
See related
Ensembl:ENSG00000172009 MIM:601117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOP; MP78; EP24.15; MEPD_HUMAN
Summary
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Expression
Broad expression in testis (RPKM 14.1), brain (RPKM 6.4) and 24 other tissues See more
Orthologs

Genomic context

See THOP1 in Genome Data Viewer
Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (2785460..2813604)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2785464..2813599)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 3 Neighboring gene small glutamine rich tetratricopeptide repeat containing alpha Neighboring gene zinc finger protein 554 Neighboring gene zinc finger protein 555

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • African trypanosomiasis, organism-specific biosystem (from KEGG)
    African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
  • African trypanosomiasis, conserved biosystem (from KEGG)
    African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
thimet oligopeptidase
Names
endopeptidase 24.15
NP_003240.1
XP_011526530.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003249.5NP_003240.1  thimet oligopeptidase

    See identical proteins and their annotated locations for NP_003240.1

    Status: REVIEWED

    Source sequence(s)
    AC006538, BC002391, BU741442, BU849088
    Consensus CDS
    CCDS12095.1
    UniProtKB/Swiss-Prot
    P52888
    Related
    ENSP00000304467.5, ENST00000307741.10
    Conserved Domains (2) summary
    cd06455
    Location:34675
    M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
    COG0339
    Location:39679
    Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    2785460..2813604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528228.2XP_011526530.1  thimet oligopeptidase isoform X1

    Conserved Domains (1) summary
    cd06455
    Location:2466
    M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin

RNA

  1. XR_001753748.1 RNA Sequence

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