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Thop1 thimet oligopeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 50492, updated on 9-May-2024

Summary

Official Symbol
Thop1provided by MGI
Official Full Name
thimet oligopeptidase 1provided by MGI
Primary source
MGI:MGI:1354165
See related
Ensembl:ENSMUSG00000004929 AllianceGenome:MGI:1354165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EP24.15
Summary
Enables metalloendopeptidase activity. Acts upstream of or within intracellular signal transduction and peptide metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial intermembrane space. Is expressed in head mesenchyme and vertebral axis musculature. Orthologous to human THOP1 (thimet oligopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 160.6), ovary adult (RPKM 53.8) and 24 other tissues See more
Orthologs
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Genomic context

See Thop1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80905917..80918194)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81070083..81082360)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16099 Neighboring gene solute carrier family 39 (zinc transporter), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E2952 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha Neighboring gene STARR-positive B cell enhancer ABC_E1808 Neighboring gene STARR-positive B cell enhancer ABC_E462 Neighboring gene cAMP responsive element binding protein 3-like 3 Neighboring gene microRNA 5615-1 Neighboring gene microRNA 5615-2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within peptide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
thimet oligopeptidase
Names
endopeptidase 24.15
NP_073144.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022653.4NP_073144.3  thimet oligopeptidase

    See identical proteins and their annotated locations for NP_073144.3

    Status: VALIDATED

    Source sequence(s)
    AK028609, BY774276, CF163503, CN723672
    Consensus CDS
    CCDS24042.1
    UniProtKB/Swiss-Prot
    Q8C1A5, Q8K0J9, Q8K2D4, Q9EPX1
    UniProtKB/TrEMBL
    A0A0R4IZY0
    Related
    ENSMUSP00000005057.7, ENSMUST00000005057.7
    Conserved Domains (2) summary
    cd06455
    Location:35675
    M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
    COG0339
    Location:37679
    Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80905917..80918194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)