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Atad2 ATPase family, AAA domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70472, updated on 11-Apr-2024

Summary

Official Symbol
Atad2provided by MGI
Official Full Name
ATPase family, AAA domain containing 2provided by MGI
Primary source
MGI:MGI:1917722
See related
Ensembl:ENSMUSG00000022360 AllianceGenome:MGI:1917722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610509G12Rik
Summary
Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; gonad; spleen; and uterus. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 11.8), CNS E11.5 (RPKM 11.6) and 19 other tissues See more
Orthologs
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Genomic context

Location:
15 D1; 15 24.32 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57957440..57998516, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58094044..58135525, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22299 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene STARR-positive B cell enhancer ABC_E941 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57966689-57966916 Neighboring gene STARR-positive B cell enhancer ABC_E3140 Neighboring gene predicted gene, 23475 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene predicted gene, 22488

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC38189

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATPase family AAA domain-containing protein 2
NP_001391691.1
NP_001391693.1
NP_001391694.1
NP_001391695.1
NP_081711.2
XP_036015476.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404762.1NP_001391691.1  ATPase family AAA domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113292
  2. NM_001404764.1NP_001391693.1  ATPase family AAA domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113292
  3. NM_001404765.1NP_001391694.1  ATPase family AAA domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113292
    UniProtKB/Swiss-Prot
    Q3UYW6, Q8CDM1
    Related
    ENSMUSP00000153936.2, ENSMUST00000228783.2
  4. NM_001404766.1NP_001391695.1  ATPase family AAA domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113292
  5. NM_027435.3NP_081711.2  ATPase family AAA domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081711.2

    Status: VALIDATED

    Source sequence(s)
    AC113292
    Consensus CDS
    CCDS37079.1
    UniProtKB/TrEMBL
    G3X963
    Related
    ENSMUSP00000043691.4, ENSMUST00000038194.5
    Conserved Domains (3) summary
    cd05528
    Location:9601070
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:438579
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:443577
    AAA; ATPase family associated with various cellular activities (AAA)

RNA

  1. NR_175863.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113292

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    57957440..57998516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159583.1XP_036015476.1  ATPase family AAA domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd05528
    Location:459569
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:3406
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    TIGR01243
    Location:3172
    CDC48; AAA family ATPase, CDC48 subfamily
    cl38936
    Location:174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153199.1: Suppressed sequence

    Description
    NM_153199.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.