Format

Send to:

Choose Destination

ATAD2 ATPase family AAA domain containing 2 [ Homo sapiens (human) ]

Gene ID: 29028, updated on 13-Feb-2019

Summary

Official Symbol
ATAD2provided by HGNC
Official Full Name
ATPase family AAA domain containing 2provided by HGNC
Primary source
HGNC:HGNC:30123
See related
Ensembl:ENSG00000156802 MIM:611941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANCCA; CT137; PRO2000
Summary
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues See more
Orthologs

Genomic context

See ATAD2 in Genome Data Viewer
Location:
8q24.13
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (123319850..123396465, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124332090..124408705, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene RNA, U6 small nuclear 628, pseudogene Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene RNA, U6 small nuclear 875, pseudogene Neighboring gene microRNA 548aa-1 Neighboring gene microRNA 548d-1 Neighboring gene deoxyuridine triphosphatase pseudogene 2 Neighboring gene uncharacterized LOC105375737 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5254, MGC29843, MGC131938, MGC142216, DKFZp667N1320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATPase family AAA domain-containing protein 2
Names
AAA nuclear coregulator cancer-associated protein
NP_054828.2
XP_011515296.1
XP_011515297.1
XP_011515298.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014109.4NP_054828.2  ATPase family AAA domain-containing protein 2

    See identical proteins and their annotated locations for NP_054828.2

    Status: REVIEWED

    Source sequence(s)
    BC113656, BP314109, CA441499, CB159561
    Consensus CDS
    CCDS6343.1
    UniProtKB/Swiss-Prot
    Q6PL18
    UniProtKB/TrEMBL
    A0A024R9G7
    Related
    ENSP00000287394.5, ENST00000287394.9
    Conserved Domains (4) summary
    cd05528
    Location:9871097
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:459600
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:9151153
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:464598
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    123319850..123396465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516994.3XP_011515296.1  ATPase family AAA domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd05528
    Location:9871097
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    smart00382
    Location:459600
    AAA; ATPases associated with a variety of cellular activities
    COG5076
    Location:9151160
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam00004
    Location:464598
    AAA; ATPase family associated with various cellular activities (AAA)
  2. XM_011516996.3XP_011515298.1  ATPase family AAA domain-containing protein 2 isoform X3

    Related
    ENSP00000429213.1, ENST00000521903.5
    Conserved Domains (2) summary
    cd05528
    Location:446556
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    cl21455
    Location:1757
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011516995.3XP_011515297.1  ATPase family AAA domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    smart00382
    Location:459600
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:464598
    AAA; ATPase family associated with various cellular activities (AAA)

RNA

  1. XR_928326.3 RNA Sequence

    Related
    ENST00000517666.5
Support Center