Tspan15 tetraspanin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan15provided by MGI
Official Full Name: tetraspanin 15provided by MGI
Primary source: MGI:MGI:1917673
See related: Ensembl:ENSMUSG00000037031 AllianceGenome:MGI:1917673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tm4sf15; 1110036D12Rik; 2700063A19Rik
Summary: Enables enzyme binding activity. Involved in protein maturation. Located in cell surface and tetraspanin-enriched microdomain. Is expressed in hypothalamus ventricular layer and pancreas epithelium. Orthologous to human TSPAN15 (tetraspanin 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 37.0), duodenum adult (RPKM 31.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 B4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62021175..62067055, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62185396..62231276, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Title: The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Data show that tetraspanin15 (Tspan15) is abundantly expressed in brain, where it specifically interacts with endogenous a disintegrin and metalloproteinase 10 (ADAM10).
Title: In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

General gene information

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Markers

D10Chm206 (e-PCR)
- UniSTS:518213

AW048364 (e-PCR)
- UniSTS:180045

Homology

Homologs of the Tspan15 gene: The Tspan15 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 494 organisms have orthologs with human gene Tspan15
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tetraspanin-15

Names: transmembrane 4 superfamily member 15; tspan-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_197996.2 → NP_932113.2 tetraspanin-15

See identical proteins and their annotated locations for NP_932113.2

Status: VALIDATED

Source sequence(s)

AC127417, CN455615, CX206586

Consensus CDS

CCDS56705.1

UniProtKB/Swiss-Prot

F7BWT7, Q3TA07

UniProtKB/TrEMBL

A0A8C6IJ46

Related

ENSMUSP00000047029.10, ENSMUST00000047883.11

Conserved Domains (2) summary

cd03158
Location:114 → 231

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:19 → 256

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

62021175..62067055 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514080.1 → XP_006514143.1 tetraspanin-15 isoform X2

Conserved Domains (1) summary

cd03158
Location:42 → 159

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
XM_011243561.3 → XP_011241863.1 tetraspanin-15 isoform X3

Conserved Domains (1) summary

cd03158
Location:18 → 133

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
XM_011243560.4 → XP_011241862.1 tetraspanin-15 isoform X1

Conserved Domains (2) summary

cd03158
Location:114 → 209

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:20 → 192

Tetraspannin; Tetraspanin family