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TSPAN15 tetraspanin 15 [ Homo sapiens (human) ]

Gene ID: 23555, updated on 10-Oct-2019

Summary

Official Symbol
TSPAN15provided by HGNC
Official Full Name
tetraspanin 15provided by HGNC
Primary source
HGNC:HGNC:23298
See related
Ensembl:ENSG00000099282 MIM:613140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET7; NET-7; TM4SF15; 2700063A19Rik
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 7.7), stomach (RPKM 7.1) and 21 other tissues See more
Orthologs

Genomic context

See TSPAN15 in Genome Data Viewer
Location:
10q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (69451464..69549508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71176821..71271569)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2430 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 14270 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC105378345 Neighboring gene uncharacterized LOC101929021 Neighboring gene NEUROG3 upstream region homotypic clusters of transcription factor binding sites enhancer Neighboring gene neurogenin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
tetraspanin-enriched microdomain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-15
Names
tetraspan NET-7
transmembrane 4 superfamily member 15
transmembrane 4 superfamily member tetraspan NET-7
tspan-15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351263.1NP_001338192.1  tetraspanin-15 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AI612860, AJ710178, BM972680, CA454790, DR158973
    Conserved Domains (1) summary
    cd03158
    Location:33144
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. NM_012339.5NP_036471.1  tetraspanin-15 isoform 1

    See identical proteins and their annotated locations for NP_036471.1

    Status: REVIEWED

    Source sequence(s)
    AC016821, AI612860, BC003157, BM972680, CA454790, DR158973
    Consensus CDS
    CCDS7294.1
    UniProtKB/Swiss-Prot
    O95858
    Related
    ENSP00000362387.2, ENST00000373290.7
    Conserved Domains (1) summary
    cd03158
    Location:114231
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. NR_147091.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016821, AI612860, AJ710178, BM972680, BP374322, CA454790, DR158973

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    69451464..69549508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016010.1XP_016871499.1  tetraspanin-15 isoform X1

  2. XM_005269666.4XP_005269723.1  tetraspanin-15 isoform X2

    Conserved Domains (2) summary
    cd03158
    Location:55166
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:57191
    Tetraspannin; Tetraspanin family
  3. XM_011539562.2XP_011537864.1  tetraspanin-15 isoform X3

    Conserved Domains (2) summary
    cd03158
    Location:4115
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:3140
    Tetraspannin; Tetraspanin family
  4. XM_011539563.2XP_011537865.1  tetraspanin-15 isoform X4

    Conserved Domains (2) summary
    cd03158
    Location:187
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1112
    Tetraspannin; Tetraspanin family

RNA

  1. XR_001747072.1 RNA Sequence

  2. XR_001747073.1 RNA Sequence

  3. XR_001747074.1 RNA Sequence

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