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TSPAN15 tetraspanin 15 [ Homo sapiens (human) ]

Gene ID: 23555, updated on 6-Nov-2022

Summary

Official Symbol
TSPAN15provided by HGNC
Official Full Name
tetraspanin 15provided by HGNC
Primary source
HGNC:HGNC:23298
See related
Ensembl:ENSG00000099282 MIM:613140; AllianceGenome:HGNC:23298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET7; NET-7; TM4SF15; 2700063A19Rik
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 7.7), stomach (RPKM 7.1) and 21 other tissues See more
Orthologs
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Genomic context

See TSPAN15 in Genome Data Viewer
Location:
10q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (69451465..69549508)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (70319512..70375725)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71211221..71267422)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2430 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 14270 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC105378345 Neighboring gene uncharacterized LOC101929021 Neighboring gene NEUROG3 upstream region homotypic clusters of transcription factor binding sites enhancer Neighboring gene neurogenin 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in tetraspanin-enriched microdomain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetraspanin-15
Names
tetraspan NET-7
transmembrane 4 superfamily member 15
transmembrane 4 superfamily member tetraspan NET-7
tspan-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351263.2NP_001338192.1  tetraspanin-15 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC016821, AI612860, BM972680, CA454790, DR158973
    Conserved Domains (1) summary
    cd03158
    Location:33144
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. NM_012339.5NP_036471.1  tetraspanin-15 isoform 1

    See identical proteins and their annotated locations for NP_036471.1

    Status: REVIEWED

    Source sequence(s)
    AC016821, AI612860, BC003157, BM972680, CA454790, DR158973
    Consensus CDS
    CCDS7294.1
    UniProtKB/Swiss-Prot
    O95858, Q6UW79
    Related
    ENSP00000362387.2, ENST00000373290.7
    Conserved Domains (1) summary
    cd03158
    Location:114231
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. NR_147091.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016821, AI612860, BM972680, BP374322, CA454790, DR158973

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    69451465..69549508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016010.2XP_016871499.1  tetraspanin-15 isoform X1

  2. XM_047424930.1XP_047280886.1  tetraspanin-15 isoform X3

  3. XM_005269666.5XP_005269723.1  tetraspanin-15 isoform X2

    Conserved Domains (2) summary
    cd03158
    Location:55166
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:57191
    Tetraspannin; Tetraspanin family
  4. XM_011539563.3XP_011537865.1  tetraspanin-15 isoform X5

    Conserved Domains (2) summary
    cd03158
    Location:187
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1112
    Tetraspannin; Tetraspanin family
  5. XM_011539562.3XP_011537864.1  tetraspanin-15 isoform X4

    Conserved Domains (2) summary
    cd03158
    Location:4115
    penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:3140
    Tetraspannin; Tetraspanin family

RNA

  1. XR_001747072.2 RNA Sequence

  2. XR_007061951.1 RNA Sequence

  3. XR_007061952.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    70319512..70375725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)