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Lman1 lectin, mannose-binding, 1 [ Mus musculus (house mouse) ]

Gene ID: 70361, updated on 8-Feb-2024

Summary

Official Symbol
Lman1provided by MGI
Official Full Name
lectin, mannose-binding, 1provided by MGI
Primary source
MGI:MGI:1917611
See related
Ensembl:ENSMUSG00000041891 AllianceGenome:MGI:1917611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P58; MR60; gp58; F5F8D; MCFD1; ERGIC53; C730041J05; 2610020P13Rik
Summary
Predicted to enable identical protein binding activity and mannose binding activity. Acts upstream of or within endoplasmic reticulum organization. Located in several cellular components, including COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum-Golgi intermediate compartment; and sarcomere. Is expressed in pancreas epithelium. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 37.0), limb E14.5 (RPKM 32.3) and 28 other tissues See more
Orthologs
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Genomic context

See Lman1 in Genome Data Viewer
Location:
18 E1; 18 39.08 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66113810..66135706, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65980739..66002635, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene retina and anterior neural fold homeobox Neighboring gene complexin 4 Neighboring gene STARR-positive B cell enhancer ABC_E1962 Neighboring gene STARR-seq mESC enhancer starr_44856 Neighboring gene collagen and calcium binding EGF domains 1 Neighboring gene STARR-seq mESC enhancer starr_44857 Neighboring gene microRNA 694 Neighboring gene STARR-seq mESC enhancer starr_44859 Neighboring gene predicted gene 15958

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein ERGIC-53
Names
ER-Golgi intermediate compartment 53 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172062.1NP_001165533.1  protein ERGIC-53 precursor

    See identical proteins and their annotated locations for NP_001165533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC152076, AK011495, BY766745
    Consensus CDS
    CCDS29313.1
    UniProtKB/Swiss-Prot
    Q9D0F3
    UniProtKB/TrEMBL
    Q3U944
    Related
    ENSMUSP00000158495.2, ENSMUST00000236866.2
    Conserved Domains (1) summary
    cd06902
    Location:52276
    lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain
  2. NM_027400.3NP_081676.1  protein ERGIC-53 precursor

    See identical proteins and their annotated locations for NP_081676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK011495, BF662012, BY766745, CN536547, DV043207, DV659063
    Consensus CDS
    CCDS29313.1
    UniProtKB/Swiss-Prot
    Q9D0F3
    UniProtKB/TrEMBL
    Q3U944
    Related
    ENSMUSP00000040140.8, ENSMUST00000048260.15
    Conserved Domains (1) summary
    cd06902
    Location:52276
    lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    66113810..66135706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)