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LMAN1 lectin, mannose binding 1 [ Homo sapiens (human) ]

Gene ID: 3998, updated on 8-Jul-2021

Summary

Official Symbol
LMAN1provided by HGNC
Official Full Name
lectin, mannose binding 1provided by HGNC
Primary source
HGNC:HGNC:6631
See related
Ensembl:ENSG00000074695 MIM:601567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MR60; gp58; F5F8D; FMFD1; MCFD1; ERGIC53; ERGIC-53
Summary
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in thyroid (RPKM 65.5), liver (RPKM 54.8) and 25 other tissues See more
Orthologs
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Genomic context

See LMAN1 in Genome Data Viewer
Location:
18q21.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (59327823..59359265, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (56995055..57026497, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene retina and anterior neural fold homeobox Neighboring gene complexin 4 Neighboring gene uncharacterized LOC107985156 Neighboring gene meiotic recombination hotspot N Neighboring gene collagen and calcium binding EGF domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env Activation of the classical complement pathway by HIV-1 gp120 is initiated by the binding of MBP to carbohydrate side chains of gp120 PubMed
env Treatment of HIV-1 gp120 with endoglycosidase H (eH) or endoglycosidase F1 (eF1) abrogates binding of MBL PubMed
env DC-SIGN and MBL bind primarily to glycans on HIV-1 gp120/gp41; preincubation of CXCR4-, CCR5- or dual-tropic HIV-1 strains with MBL prevents DC-SIGN-mediated trans infection of T cells PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with LMAN1; predicted interaction to be within the endoplasmic reticulum PubMed
env HIV-1 gp160 is identified to have a physical interaction with lectin, mannose-binding 1 (LMAN1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with lectin, mannose-binding 1 (LMAN1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env DC-SIGN and MBL bind primarily to glycans on HIV-1 gp120gp41; preincubation of CXCR4-, CCR5- or dual-tropic HIV-1 strains with MBL prevents DC-SIGN-mediated trans infection of T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein ERGIC-53
Names
ER-Golgi intermediate compartment 53 kDa protein
endoplasmic reticulum-golgi intermediate compartment protein 53
intracellular mannose-specific lectin MR60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012097.1 RefSeqGene

    Range
    5012..36454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_595

mRNA and Protein(s)

  1. NM_005570.4NP_005561.1  protein ERGIC-53 precursor

    See identical proteins and their annotated locations for NP_005561.1

    Status: REVIEWED

    Source sequence(s)
    AC016229, AC067859, AI280513, AK025773, BC032330, DC308886, U09716
    Consensus CDS
    CCDS11974.1
    UniProtKB/Swiss-Prot
    P49257
    UniProtKB/TrEMBL
    A0A024R2A7
    Related
    ENSP00000251047.4, ENST00000251047.6
    Conserved Domains (1) summary
    cd06902
    Location:44268
    lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    59327823..59359265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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