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St13 suppression of tumorigenicity 13 [ Mus musculus (house mouse) ]

Gene ID: 70356, updated on 2-Nov-2024

Summary

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Official Symbol
St13provided by MGI
Official Full Name
suppression of tumorigenicity 13provided by MGI
Primary source
MGI:MGI:1917606
See related
Ensembl:ENSMUSG00000022403 AllianceGenome:MGI:1917606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIP; HOP; p48; SNC6; HSPABP; HSPABP1; PRO0786; 1110007I03Rik; 3110002K08Rik
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; dATP binding activity; and unfolded protein binding activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 66.5), CNS E11.5 (RPKM 53.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See St13 in Genome Data Viewer
Location:
15 E1; 15 38.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81247869..81284278, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81365044..81399694, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52179 Neighboring gene solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 Neighboring gene STARR-positive B cell enhancer mm9_chr15:81163002-81163302 Neighboring gene STARR-seq mESC enhancer starr_39251 Neighboring gene STARR-positive B cell enhancer ABC_E2445 Neighboring gene STARR-positive B cell enhancer ABC_E7396 Neighboring gene X-prolyl aminopeptidase 3, mitochondrial Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene predicted gene 17025

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis. Cao RC, et al. J Transl Med, 2022 May 13. PMID 35562743, Free PMC Article
  2. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
  3. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. Fan X, et al. Elife, 2021 Feb 8. PMID 33554859, Free PMC Article
  4. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.
    Title: St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables dATP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein refolding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hsc70-interacting protein
Names
Hsp70 interacting protein
protein ST13 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418649.1 → NP_001405578.1  hsc70-interacting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109153
    UniProtKB/Swiss-Prot
    Q4FJT4, Q99L47

  2. NM_001418650.1 → NP_001405579.1  hsc70-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109153

  3. NM_001418651.1 → NP_001405580.1  hsc70-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109153

  4. NM_001418652.1 → NP_001405581.1  hsc70-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109153

  5. NM_001418653.1 → NP_001405582.1  hsc70-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109153

  6. NM_001418654.1 → NP_001405583.1  hsc70-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109153

  7. NM_133726.3 → NP_598487.1  hsc70-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_598487.1

    Status: VALIDATED

    Source sequence(s)
    AC109153
    Consensus CDS
    CCDS27667.1
    UniProtKB/Swiss-Prot
    Q4FJT4, Q99L47
    UniProtKB/TrEMBL
    Q3U3N7, Q3U8D2, Q3U9V1
    Related
    ENSMUSP00000130195.2, ENSMUST00000172107.8
    Conserved Domains (5) summary
    smart00727
    Location:321 → 360
    STI1; Heat shock chaperonin-binding motif
    cd14438
    Location:3 → 43
    Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
    sd00006
    Location:113 → 141
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:147 → 179
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:112 → 178
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81247869..81284278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L47.1 GenPept UniProtKB/Swiss-Prot:Q99L47

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