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ST13 ST13 Hsp70 interacting protein [ Homo sapiens (human) ]

Gene ID: 6767, updated on 12-Oct-2019

Summary

Official Symbol
ST13provided by HGNC
Official Full Name
ST13 Hsp70 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:11343
See related
Ensembl:ENSG00000100380 MIM:606796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786
Summary
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in ovary (RPKM 177.9), kidney (RPKM 97.3) and 25 other tissues See more
Orthologs

Genomic context

See ST13 in Genome Data Viewer
Location:
22q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (40824535..40857008, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41220539..41253012, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 17 Neighboring gene jumping translocation breakpoint pseudogene 1 Neighboring gene microRNA 4766 Neighboring gene X-prolyl aminopeptidase 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene RNA, U6 small nuclear 379, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27260, MGC129952

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
dATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging TAS
Traceable Author Statement
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein refolding IEA
Inferred from Electronic Annotation
more info
 
protein folding TAS
Traceable Author Statement
more info
PubMed 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hsc70-interacting protein
Names
Hsp70-interacting protein
aging-associated protein 2
heat shock 70kD protein binding protein
progesterone receptor-associated p48 protein
putative tumor suppressor ST13
renal carcinoma antigen NY-REN-33
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
suppression of tumorigenicity 13 protein
testis secretory sperm-binding protein Li 233m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278589.1NP_001265518.1  hsc70-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001265518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK303530, BM679025, Z98048
    UniProtKB/TrEMBL
    B4E0U6
    Conserved Domains (5) summary
    smart00727
    Location:309348
    STI1; Heat shock chaperonin-binding motif
    cd14438
    Location:343
    Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
    sd00006
    Location:137167
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:138170
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:103169
    TPR_11; TPR repeat
  2. NM_003932.5NP_003923.2  hsc70-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_003923.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC121107, BM679025, U17714, Z98048
    Consensus CDS
    CCDS14006.1
    UniProtKB/Swiss-Prot
    P50502
    UniProtKB/TrEMBL
    A0A140VKA6, Q0IJ56
    Related
    ENSP00000216218.3, ENST00000216218.8
    Conserved Domains (4) summary
    smart00727
    Location:319358
    STI1; Heat shock chaperonin-binding motif
    cd14438
    Location:343
    Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
    sd00006
    Location:147177
    TPR; TPR repeat [structural motif]
    cl26005
    Location:114233
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    40824535..40857008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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