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Ppp4r1 protein phosphatase 4, regulatory subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 70351, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp4r1provided by MGI
Official Full Name
protein phosphatase 4, regulatory subunit 1provided by MGI
Primary source
MGI:MGI:1917601
See related
Ensembl:ENSMUSG00000061950 AllianceGenome:MGI:1917601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp4r1; 3110001J10Rik
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be active in cytoplasm. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP4R1 (protein phosphatase 4 regulatory subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 40.7), CNS E14 (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp4r1 in Genome Data Viewer
Location:
17 E1.1; 17 35.26 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66089253..66148921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65782543..65841926)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene RAB31, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022 Neighboring gene STARR-seq mESC enhancer starr_43025 Neighboring gene STARR-seq mESC enhancer starr_43027 Neighboring gene ralA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10964 Neighboring gene predicted gene, 49870 Neighboring gene predicted gene, 35550

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes. Wang S, et al. Mol Med Rep, 2018 Oct. PMID 30132533
  2. Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes. Hwang J, et al. J Biol Chem, 2016 Sep 30. PMID 27507813, Free PMC Article
  3. PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress. Zhu X, et al. Biochim Biophys Acta Mol Cell Res, 2024 Jan. PMID 37739270
  4. AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner. Xu W, et al. Cell Death Differ, 2024 May. PMID 38424148,
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
    Title: AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
  2. PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress.
    Title: PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress.
  3. miR3383p may be involved in TNFalphamediated gluconeogenesis via targeting of PP4R1 in hepatocytes.
    Title: miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes.
  4. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.
    Title: Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC31567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114131.1 → NP_001107603.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, CX568699
    Consensus CDS
    CCDS50167.1
    UniProtKB/TrEMBL
    E9PX53, Q3TLM9
    Related
    ENSMUSP00000124690.2, ENSMUST00000160664.8
    Conserved Domains (2) summary
    pfam15017
    Location:419 → 475
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:116 → 140
    HEAT; HEAT repeat [structural motif]

  2. NM_146081.2 → NP_666193.2  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, BY163631, CX568699
    Consensus CDS
    CCDS28941.2
    UniProtKB/Swiss-Prot
    Q8K2V1, Q8R0R8
    UniProtKB/TrEMBL
    E9QPR5
    Related
    ENSMUSP00000072848.5, ENSMUST00000073104.11
    Conserved Domains (2) summary
    pfam15017
    Location:436 → 492
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:133 → 157
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_104465.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139751, AK133969, AK167713, BI135060
    Related
    ENSMUST00000162109.8

  2. NR_152099.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139751, BI135060, CT025659

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    66089253..66148921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524889.5 → XP_006524952.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524952.1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  2. XM_006524890.5 → XP_006524953.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524953.1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  3. XM_006524888.5 → XP_006524951.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524951.1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  4. XM_030250045.2 → XP_030105905.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  5. XM_030250046.2 → XP_030105906.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  6. XM_030250047.2 → XP_030105907.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3

    Conserved Domains (2) summary
    sd00044
    Location:316 → 344
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:105 → 123
    WRNPLPNID; Putative WW-binding domain and destruction box

  7. XM_006524891.5 → XP_006524954.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524954.1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  8. XM_006524892.5 → XP_006524955.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524955.1

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (2) summary
    sd00044
    Location:90 → 114
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:411 → 427
    WRNPLPNID; Putative WW-binding domain and destruction box

  9. XM_036160783.1 → XP_036016676.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

    UniProtKB/TrEMBL
    Q3TLM9
    Conserved Domains (3) summary
    sd00044
    Location:16 → 47
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:57 → 84
    HEAT; HEAT repeat
    pfam15017
    Location:258 → 292
    WRNPLPNID; Putative WW-binding domain and destruction box

  10. XM_006524895.5 → XP_006524958.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_006524958.1

    UniProtKB/Swiss-Prot
    Q8K2V1
    Conserved Domains (2) summary
    sd00044
    Location:316 → 344
    HEAT; HEAT repeat [structural motif]
    pfam15017
    Location:105 → 123
    WRNPLPNID; Putative WW-binding domain and destruction box

RNA

  1. XR_003952177.1 RNA Sequence

  2. XR_001782110.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2V1.2 GenPept UniProtKB/Swiss-Prot:Q8K2V1

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