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Ppp4r1 protein phosphatase 4, regulatory subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 70351, updated on 31-Jan-2019

Summary

Official Symbol
Ppp4r1provided by MGI
Official Full Name
protein phosphatase 4, regulatory subunit 1provided by MGI
Primary source
MGI:MGI:1917601
See related
Ensembl:ENSMUSG00000061950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp4r1; 3110001J10Rik
Expression
Ubiquitous expression in testis adult (RPKM 40.7), CNS E14 (RPKM 12.0) and 28 other tissues See more
Orthologs

Genomic context

See Ppp4r1 in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (65782378..65841926)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (66132695..66191266)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene RAB31, member RAS oncogene family Neighboring gene ralA binding protein 1 Neighboring gene predicted gene, 35550

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Homology

Clone Names

  • MGC31567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
protein phosphatase 4 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114131.1NP_001107603.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, CX568699
    Consensus CDS
    CCDS50167.1
    UniProtKB/Swiss-Prot
    Q8K2V1
    UniProtKB/TrEMBL
    E9PX53, Q3TLM9
    Related
    ENSMUSP00000124690.1, ENSMUST00000160664.7
    Conserved Domains (2) summary
    pfam15017
    Location:419475
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:116140
    HEAT; HEAT repeat [structural motif]
  2. NM_146081.2NP_666193.2  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, BY163631, CX568699
    Consensus CDS
    CCDS28941.2
    UniProtKB/Swiss-Prot
    Q8K2V1
    UniProtKB/TrEMBL
    E9QPR5, Q3TLM9
    Related
    ENSMUSP00000072848.4, ENSMUST00000073104.10
    Conserved Domains (2) summary
    pfam15017
    Location:436492
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:133157
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_104465.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139751, AK133969, AK167713, BI135060
    Related
    ENSMUST00000162109.7
  2. NR_152099.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139751, BI135060, CT025659

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    65782378..65841926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524890.3XP_006524953.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524953.1

    Conserved Domains (2) summary
    pfam15017
    Location:393449
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:90114
    HEAT; HEAT repeat [structural motif]
  2. XM_006524889.3XP_006524952.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524952.1

    Conserved Domains (2) summary
    pfam15017
    Location:393449
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:90114
    HEAT; HEAT repeat [structural motif]
  3. XM_006524888.3XP_006524951.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524951.1

    Conserved Domains (2) summary
    pfam15017
    Location:393449
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:90114
    HEAT; HEAT repeat [structural motif]
  4. XM_006524894.3XP_006524957.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

    See identical proteins and their annotated locations for XP_006524957.1

    UniProtKB/Swiss-Prot
    Q8K2V1
    Conserved Domains (2) summary
    pfam15017
    Location:87126
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:316344
    HEAT; HEAT repeat [structural motif]
  5. XM_006524891.3XP_006524954.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524954.1

    Conserved Domains (2) summary
    pfam15017
    Location:393449
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:90114
    HEAT; HEAT repeat [structural motif]
  6. XM_006524892.3XP_006524955.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006524955.1

    Conserved Domains (2) summary
    pfam15017
    Location:393449
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:90114
    HEAT; HEAT repeat [structural motif]
  7. XM_006524895.3XP_006524958.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

    See identical proteins and their annotated locations for XP_006524958.1

    UniProtKB/Swiss-Prot
    Q8K2V1
    Conserved Domains (2) summary
    pfam15017
    Location:87126
    AF1Q; Drug resistance and apoptosis regulator
    sd00044
    Location:316344
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_001782110.1 RNA Sequence

  2. XR_001782111.1 RNA Sequence

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