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Hdac8 histone deacetylase 8 [ Mus musculus (house mouse) ]

Gene ID: 70315, updated on 3-Jun-2018
Official Symbol
Hdac8provided by MGI
Official Full Name
histone deacetylase 8provided by MGI
Primary source
MGI:MGI:1917565
See related
Ensembl:ENSMUSG00000067567 Vega:OTTMUSG00000017208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610007D20Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.0) and 28 other tissues See more
Orthologs
See Hdac8 in Genome Data Viewer
Location:
X; X D
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (102284638..102507710, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (99479979..99700487, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene predicted gene 14858 Neighboring gene predicted gene, 32262 Neighboring gene phosphorylase kinase alpha 1 Neighboring gene transcriptional adaptor 3 pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase activity TAS
Traceable Author Statement
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chromatin organization TAS
Traceable Author Statement
more info
PubMed 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of cohesin loading ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
histone deacetylase 8
Names
HD8
NP_001300671.1
NP_081658.1
XP_006528338.1
XP_006528339.1
XP_011245972.1
XP_011245973.1
XP_011245975.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313742.1NP_001300671.1  histone deacetylase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK034511, AK131998
    UniProtKB/Swiss-Prot
    Q8VH37
    Conserved Domains (1) summary
    cl17011
    Location:16246
    Arginase_HDAC; Arginase-like and histone-like hydrolases
  2. NM_027382.4NP_081658.1  histone deacetylase 8 isoform 1

    See identical proteins and their annotated locations for NP_081658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK131998, AL954850
    Consensus CDS
    CCDS41084.1
    UniProtKB/Swiss-Prot
    Q8VH37
    Related
    ENSMUSP00000085226.4, OTTMUSP00000018717, ENSMUST00000087916.10, OTTMUST00000041672
    Conserved Domains (1) summary
    cd10000
    Location:16377
    HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    102284638..102507710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528275.3XP_006528338.1  histone deacetylase 8 isoform X1

    Conserved Domains (1) summary
    cd10000
    Location:16370
    HDAC8; Histone deacetylase 8 (HDAC8)
  2. XM_006528276.3XP_006528339.1  histone deacetylase 8 isoform X3

    Conserved Domains (1) summary
    cd10000
    Location:16335
    HDAC8; Histone deacetylase 8 (HDAC8)
  3. XM_011247670.2XP_011245972.1  histone deacetylase 8 isoform X2

    Conserved Domains (1) summary
    cd10000
    Location:16337
    HDAC8; Histone deacetylase 8 (HDAC8)
  4. XM_011247671.2XP_011245973.1  histone deacetylase 8 isoform X4

    Conserved Domains (1) summary
    cd10000
    Location:16335
    HDAC8; Histone deacetylase 8 (HDAC8)
  5. XM_011247673.2XP_011245975.1  histone deacetylase 8 isoform X5

    Conserved Domains (1) summary
    cl17011
    Location:16153
    Arginase_HDAC; Arginase-like and histone-like hydrolases
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