Format

Send to:

Choose Destination

Hdac8 histone deacetylase 8 [ Mus musculus (house mouse) ]

Gene ID: 70315, updated on 22-Aug-2021

Summary

Official Symbol
Hdac8provided by MGI
Official Full Name
histone deacetylase 8provided by MGI
Primary source
MGI:MGI:1917565
See related
Ensembl:ENSMUSG00000067567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610007D20Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hdac8 in Genome Data Viewer
Location:
X; X D
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101328244..101549005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102284638..102505381, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (99479979..99700487, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene predicted gene 14858 Neighboring gene predicted gene, 32262 Neighboring gene phosphorylase kinase alpha 1 Neighboring gene transcriptional adaptor 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to trichostatin A ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin organization TAS
Traceable Author Statement
more info
PubMed 
involved_in histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone H3-K9 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cohesin loading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to 11-deoxycorticosterone ISO
Inferred from Sequence Orthology
more info
 
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone deacetylase 8
Names
HD8
NP_001300671.1
NP_081658.1
XP_006528338.1
XP_006528339.1
XP_011245973.1
XP_011245975.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313742.1NP_001300671.1  histone deacetylase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK034511, AK131998
    UniProtKB/Swiss-Prot
    Q8VH37
    Related
    ENSMUST00000148481.8
    Conserved Domains (1) summary
    cl17011
    Location:16246
    Arginase_HDAC; Arginase-like and histone-like hydrolases
  2. NM_027382.4NP_081658.1  histone deacetylase 8 isoform 1

    See identical proteins and their annotated locations for NP_081658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK131998, AL954850
    Consensus CDS
    CCDS41084.1
    UniProtKB/Swiss-Prot
    Q8VH37
    Related
    ENSMUSP00000085226.5, ENSMUST00000087916.11
    Conserved Domains (1) summary
    cd10000
    Location:16377
    HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    101328244..101549005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528276.5XP_006528339.1  histone deacetylase 8 isoform X2

    Conserved Domains (1) summary
    cd10000
    Location:16335
    HDAC8; Histone deacetylase 8 (HDAC8)
  2. XM_006528275.5XP_006528338.1  histone deacetylase 8 isoform X1

    Conserved Domains (1) summary
    cd10000
    Location:16370
    HDAC8; Histone deacetylase 8 (HDAC8)
  3. XM_011247671.4XP_011245973.1  histone deacetylase 8 isoform X3

    Conserved Domains (1) summary
    cd10000
    Location:16335
    HDAC8; Histone deacetylase 8 (HDAC8)
  4. XM_011247673.4XP_011245975.1  histone deacetylase 8 isoform X4

    Conserved Domains (1) summary
    cl17011
    Location:16153
    Arginase_HDAC; Arginase-like and histone-like hydrolases

RNA

  1. XR_004940364.1 RNA Sequence

Support Center