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Cactin cactin, spliceosome C complex subunit [ Mus musculus (house mouse) ]

Gene ID: 70312, updated on 11-Apr-2024

Summary

Official Symbol
Cactinprovided by MGI
Official Full Name
cactin, spliceosome C complex subunitprovided by MGI
Primary source
MGI:MGI:1917562
See related
Ensembl:ENSMUSG00000034889 AllianceGenome:MGI:1917562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510012J08Rik
Summary
Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Predicted to act upstream of or within RNA splicing; innate immune response; and mRNA processing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm. Orthologous to human CACTIN (cactin, spliceosome C complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 25.3), ovary adult (RPKM 19.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 39.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81156937..81162085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81321103..81326251)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene tight junction protein 3 Neighboring gene STARR-seq mESC enhancer starr_27326 Neighboring gene STARR-positive B cell enhancer ABC_E301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80760144-80760253 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80760802-80760911 Neighboring gene predicted gene 16315 Neighboring gene thromboxane A2 receptor Neighboring gene GIPC PDZ domain containing family, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027381.2NP_081657.1  splicing factor Cactin

    See identical proteins and their annotated locations for NP_081657.1

    Status: VALIDATED

    Source sequence(s)
    AY934504, BC150986, BY651766
    Consensus CDS
    CCDS35995.1
    UniProtKB/Swiss-Prot
    Q9CS00
    UniProtKB/TrEMBL
    A1L013
    Related
    ENSMUSP00000059533.7, ENSMUST00000050867.8
    Conserved Domains (3) summary
    pfam09732
    Location:648772
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
    pfam10312
    Location:292477
    Cactin_mid; Conserved mid region of cactin
    pfam14943
    Location:232319
    MRP-S26; Mitochondrial ribosome subunit S26

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81156937..81162085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)