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CACTIN cactin, spliceosome C complex subunit [ Homo sapiens (human) ]

Gene ID: 58509, updated on 5-Feb-2023

Summary

Official Symbol
CACTINprovided by HGNC
Official Full Name
cactin, spliceosome C complex subunitprovided by HGNC
Primary source
HGNC:HGNC:29938
See related
Ensembl:ENSG00000105298 MIM:618536; AllianceGenome:HGNC:29938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
fSAPc; C19orf29; NY-REN-24
Summary
Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 5.5), testis (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See CACTIN in Genome Data Viewer
Location:
19p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3610645..3626790, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3588768..3604917, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3610643..3626788, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene GIPC PDZ domain containing family member 3 Neighboring gene thromboxane A2 receptor Neighboring gene CACTIN antisense RNA 1 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene Sharpr-MPRA regulatory region 323 Neighboring gene Sharpr-MPRA regulatory region 5698

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17482, FLJ59622

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
splicing factor Cactin; cactin
Names
NY REN 24 antigen
functional spliceosome-associated protein c
renal carcinoma antigen NY-REN-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080543.2NP_001074012.1  splicing factor Cactin

    See identical proteins and their annotated locations for NP_001074012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005175, AW027691, BF196424, CF272634, CN305928, CO248922
    Consensus CDS
    CCDS45920.1
    UniProtKB/Swiss-Prot
    Q8WUQ7, Q9Y5A4
    Related
    ENSP00000415078.1, ENST00000429344.7
    Conserved Domains (3) summary
    pfam09732
    Location:634758
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
    pfam10312
    Location:270455
    Cactin_mid; Conserved mid region of cactin
    pfam14738
    Location:213304
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
  2. NM_021231.2NP_067054.1  splicing factor Cactin

    See identical proteins and their annotated locations for NP_067054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005175, AW027691, BC019848, BF196424, CF272634, CN305928, CO248922
    Consensus CDS
    CCDS45920.1
    UniProtKB/Swiss-Prot
    Q8WUQ7, Q9Y5A4
    Related
    ENSP00000248420.5, ENST00000248420.9
    Conserved Domains (3) summary
    pfam09732
    Location:634758
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
    pfam10312
    Location:270455
    Cactin_mid; Conserved mid region of cactin
    pfam14738
    Location:213304
    PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    3610645..3626790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528160.3XP_011526462.1  cactin isoform X1

    Conserved Domains (1) summary
    pfam10312
    Location:270452
    Cactin_mid; Conserved mid region of cactin
  2. XM_011528161.3XP_011526463.1  cactin isoform X2

    Conserved Domains (1) summary
    pfam10312
    Location:270384
    Cactin_mid; Conserved mid region of cactin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    3588768..3604917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)