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Rnf126 ring finger protein 126 [ Mus musculus (house mouse) ]

Gene ID: 70294, updated on 17-Aug-2024

Summary

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Official Symbol
Rnf126provided by MGI
Official Full Name
ring finger protein 126provided by MGI
Primary source
MGI:MGI:1917544
See related
Ensembl:ENSMUSG00000035890 AllianceGenome:MGI:1917544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610010O19Rik
Summary
Enables epidermal growth factor receptor binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and protein K63-linked ubiquitination. Predicted to be located in cytosol and nucleoplasm. Orthologous to human RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 392.3), ovary adult (RPKM 96.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79594349..79607282, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79758515..79771448, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) mitochondrial (DNA directed) Neighboring gene STARR-positive B cell enhancer ABC_E3897 Neighboring gene fibroblast growth factor 22 Neighboring gene STARR-positive B cell enhancer ABC_E899 Neighboring gene STARR-positive B cell enhancer ABC_E719 Neighboring gene follistatin-like 3 Neighboring gene serine protease 57 Neighboring gene predicted gene, 40713 Neighboring gene paralemmin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy. Liu W, et al. Adv Sci (Weinh), 2023 Feb. PMID 36563124, Free PMC Article
  2. Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair. Ishida N, et al. Mol Cell Biol, 2017 Feb 15. PMID 27895153, Free PMC Article
  3. The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor. Smith CJ, et al. Exp Cell Res, 2014 Jan 15. PMID 24275455
  4. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Smith CJ, et al. J Cell Sci, 2013 Mar 15. PMID 23418353
  5. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.
    Title: RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasm protein quality control by the ubiquitin-proteasome system ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF126
NP_653111.1
XP_006514138.1
XP_017169570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144528.3 → NP_653111.1  E3 ubiquitin-protein ligase RNF126

    See identical proteins and their annotated locations for NP_653111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes a functional protein.
    Source sequence(s)
    AC151828
    Consensus CDS
    CCDS23989.1
    UniProtKB/Swiss-Prot
    Q91YL2
    UniProtKB/TrEMBL
    Q3U3G2
    Related
    ENSMUSP00000039486.9, ENSMUST00000047203.9
    Conserved Domains (2) summary
    cd16801
    Location:230 → 273
    RING-H2_RNF126; RING finger, H2 subclass, found in RING finger protein 126 (RNF126) and similar proteins
    pfam14369
    Location:10 → 40
    zinc_ribbon_9; zinc-ribbon

RNA

  1. NR_027505.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it does not have an in-frame coding region, compared to variant 1.
    Source sequence(s)
    AC151828, AK042319, BU147682
    Related
    ENSMUST00000218770.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79594349..79607282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514075.4 → XP_006514138.1  E3 ubiquitin-protein ligase RNF126 isoform X2

    Conserved Domains (1) summary
    pfam14369
    Location:10 → 40
    zinc_ribbon_9; zinc-ribbon

  2. XM_017314081.2 → XP_017169570.1  E3 ubiquitin-protein ligase RNF126 isoform X1

    Conserved Domains (1) summary
    pfam14369
    Location:10 → 40
    zinc_ribbon_9; zinc-ribbon

RNA

  1. XR_001779593.3 RNA Sequence

  2. XR_004936269.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YL2.1 GenPept UniProtKB/Swiss-Prot:Q91YL2

Gene LinkOut

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