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RNF126 ring finger protein 126 [ Homo sapiens (human) ]

Gene ID: 55658, updated on 3-Oct-2020

Summary

Official Symbol
RNF126provided by HGNC
Official Full Name
ring finger protein 126provided by HGNC
Primary source
HGNC:HGNC:21151
See related
Ensembl:ENSG00000070423 MIM:615177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 15.1), spleen (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See RNF126 in Genome Data Viewer
Location:
19p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (647526..663214, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (647526..663313, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372234 Neighboring gene fibroblast growth factor 22 Neighboring gene follistatin like 3 Neighboring gene serine protease 57 Neighboring gene ribosomal protein S2 pseudogene 52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with ring finger protein 126 (RNF126) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1022, FLJ20552, MGC14317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF126
NP_001352947.1
NP_919442.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016713.1 RefSeqGene

    Range
    5014..20702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001366018.1NP_001352947.1  E3 ubiquitin-protein ligase RNF126 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004156, AC004449
    Related
    ENSP00000464945.2, ENST00000589762.5
    Conserved Domains (2) summary
    pfam14369
    Location:1040
    zinc_ribbon_9; zinc-ribbon
    cd16801
    Location:201244
    RING-H2_RNF126; RING finger, H2 subclass, found in RING finger protein 126 (RNF126) and similar proteins
  2. NM_194460.3NP_919442.1  E3 ubiquitin-protein ligase RNF126 isoform 1

    See identical proteins and their annotated locations for NP_919442.1

    Status: REVIEWED

    Source sequence(s)
    AC004156, AC004449, AK289616, BG773910
    Consensus CDS
    CCDS12039.1
    UniProtKB/Swiss-Prot
    Q9BV68
    UniProtKB/TrEMBL
    A0A024R206, A8K0Q1
    Related
    ENSP00000292363.3, ENST00000292363.10
    Conserved Domains (2) summary
    cd16801
    Location:228271
    RING-H2_RNF126; RING finger, H2 subclass, found in RING finger protein 126 (RNF126) and similar proteins
    pfam14369
    Location:1040
    zinc_ribbon_9; zinc-ribbon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    647526..663214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002958330.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017876.3: Suppressed sequence

    Description
    NM_017876.3: This RefSeq was permanently suppressed because it has a non-consensus splice site that does not have enough supporting evidence.
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