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Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [ Mus musculus (house mouse) ]

Gene ID: 70247, updated on 8-Feb-2024

Summary

Official Symbol
Psmd1provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1provided by MGI
Primary source
MGI:MGI:1917497
See related
Ensembl:ENSMUSG00000026229 AllianceGenome:MGI:1917497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S1; P112; 2410026J11Rik
Summary
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a self-compartmentalizing protease comprised of approximately 31 different subunits. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. Protein degradation by proteasomes is the source of most antigenic peptides presented on MHC class I molecules. This gene encodes a non-ATPase subunit of the 26S proteasome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 41.0), placenta adult (RPKM 37.7) and 28 other tissues See more
Orthologs
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Genomic context

See Psmd1 in Genome Data Viewer
Location:
1 C5; 1 43.94 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85992341..86067017)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86064619..86139295)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810459M11 gene Neighboring gene spermatogenesis associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E1552 Neighboring gene predicted gene, 22786 Neighboring gene predicted gene, 53570 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2B Neighboring gene STARR-seq mESC enhancer starr_01562 Neighboring gene STARR-seq mESC enhancer starr_01563 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:88051083-88051236 Neighboring gene STARR-positive B cell enhancer ABC_E4330 Neighboring gene armadillo repeat containing 9 Neighboring gene STARR-seq mESC enhancer starr_01567 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88110756-88111056 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88125353-88125654 Neighboring gene STARR-seq mESC enhancer starr_01568 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88154834-88155134 Neighboring gene predicted gene, 46098 Neighboring gene predicted gene 16341

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
26S proteasome non-ATPase regulatory subunit 1
Names
26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027357.2NP_081633.1  26S proteasome non-ATPase regulatory subunit 1

    See identical proteins and their annotated locations for NP_081633.1

    Status: PROVISIONAL

    Source sequence(s)
    AK153386
    Consensus CDS
    CCDS15117.1
    UniProtKB/Swiss-Prot
    B2RRP8, Q3TXS7
    UniProtKB/TrEMBL
    Q8CGI9
    Related
    ENSMUSP00000027432.9, ENSMUST00000027432.9
    Conserved Domains (3) summary
    COG5116
    Location:2934
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01851
    Location:651685
    PC_rep; Proteasome/cyclosome repeat
    sd00044
    Location:601624
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    85992341..86067017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)