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Ifi35 interferon-induced protein 35 [ Mus musculus (house mouse) ]

Gene ID: 70110, updated on 5-Mar-2024

Summary

Official Symbol
Ifi35provided by MGI
Official Full Name
interferon-induced protein 35provided by MGI
Primary source
MGI:MGI:1917360
See related
Ensembl:ENSMUSG00000010358 AllianceGenome:MGI:1917360
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IFP35; ifi-35; 2010008K16Rik
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of NIK/NF-kappaB signaling; positive regulation of inflammatory response; and positive regulation of innate immune response. Located in extracellular space. Is expressed in bladder. Orthologous to human IFI35 (interferon induced protein 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 43.0), duodenum adult (RPKM 34.9) and 20 other tissues See more
Orthologs
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Genomic context

See Ifi35 in Genome Data Viewer
Location:
11 D; 11 65.07 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101339238..101349527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101448412..101458701)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase 3 like Neighboring gene STARR-positive B cell enhancer ABC_E596 Neighboring gene RUN domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1431 Neighboring gene ribosomal protein L27 Neighboring gene STARR-positive B cell enhancer ABC_E7067 Neighboring gene STARR-seq mESC enhancer starr_30763 Neighboring gene vesicle amine transport 1 Neighboring gene STARR-positive B cell enhancer ABC_E11494 Neighboring gene Rho family GTPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon-induced 35 kDa protein homolog
Names
IFP 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027320.4NP_081596.1  interferon-induced 35 kDa protein homolog

    See identical proteins and their annotated locations for NP_081596.1

    Status: PROVISIONAL

    Source sequence(s)
    AL590996
    Consensus CDS
    CCDS25471.1
    UniProtKB/Swiss-Prot
    Q3V2E7, Q9D8C4
    Related
    ENSMUSP00000010502.7, ENSMUST00000010502.13
    Conserved Domains (2) summary
    pfam07292
    Location:81170
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:880
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101339238..101349527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)