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IFI35 interferon induced protein 35 [ Homo sapiens (human) ]

Gene ID: 3430, updated on 13-Mar-2020

Summary

Official Symbol
IFI35provided by HGNC
Official Full Name
interferon induced protein 35provided by HGNC
Primary source
HGNC:HGNC:5399
See related
Ensembl:ENSG00000068079 MIM:600735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFP35
Expression
Ubiquitous expression in spleen (RPKM 18.2), appendix (RPKM 14.5) and 25 other tissues See more
Orthologs

Genomic context

See IFI35 in Genome Data Viewer
Location:
17q21.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43006784..43014459)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41158742..41166476)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PTGES3L-AARSD1 readthrough Neighboring gene RUN domain containing 1 Neighboring gene ribosomal protein L27 Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-inducible protein 35 (IFI35) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFI35, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI35 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-induced 35 kDa protein
Names
IFP 35
ifi-35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330230.2NP_001317159.1  interferon-induced 35 kDa protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA827287, AC055866
    Consensus CDS
    CCDS82134.1
    UniProtKB/Swiss-Prot
    P80217
    Related
    ENSP00000394579.2, ENST00000415816.6
  2. NM_005533.5NP_005524.2  interferon-induced 35 kDa protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA740882, AA832092, BC001356, BU571030
    Consensus CDS
    CCDS11450.1
    UniProtKB/Swiss-Prot
    P80217
    Related
    ENSP00000395590.2, ENST00000438323.2
    Conserved Domains (2) summary
    pfam07292
    Location:183268
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:980
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43006784..43014459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024584.1XP_016880073.1  interferon-induced 35 kDa protein isoform X1

  2. XM_017024585.2XP_016880074.1  interferon-induced 35 kDa protein isoform X2

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