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Acot7 acyl-CoA thioesterase 7 [ Mus musculus (house mouse) ]

Gene ID: 70025, updated on 8-Feb-2024

Summary

Official Symbol
Acot7provided by MGI
Official Full Name
acyl-CoA thioesterase 7provided by MGI
Primary source
MGI:MGI:1917275
See related
Ensembl:ENSMUSG00000028937 AllianceGenome:MGI:1917275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Act; Ach1; Bach; Lach1; Cte-II; CTE-IIa; 2410041A17Rik
Summary
Enables identical protein binding activity and palmitoyl-CoA hydrolase activity. Acts upstream of or within fatty acid catabolic process. Located in several cellular components, including cell body; cytosol; and mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT7 (acyl-CoA thioesterase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 205.9), cerebellum adult (RPKM 88.3) and 17 other tissues See more
Orthologs
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Genomic context

See Acot7 in Genome Data Viewer
Location:
4 E2; 4 82.93 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152258872..152356312)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152178100..152271855)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12198 Neighboring gene predicted gene, 30622 Neighboring gene hes family bHLH transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E6292 Neighboring gene STARR-seq mESC enhancer starr_12200 Neighboring gene STARR-positive B cell enhancer ABC_E9627 Neighboring gene G protein-coupled receptor 153 Neighboring gene STARR-positive B cell enhancer ABC_E4736 Neighboring gene STARR-positive B cell enhancer ABC_E3558 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables long-chain fatty acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables thiolester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic acyl coenzyme A thioester hydrolase
Names
50-kDa brain acyl-CoA hydrolase
brain acyl-CoA hydrolase
long chain acyl-CoA thioester hydrolase
NP_001139529.2
NP_001139530.1
NP_001356202.1
NP_001356203.1
NP_001356204.1
NP_001356205.1
NP_579926.2
XP_006539232.1
XP_030109627.1
XP_030109628.1
XP_030109629.1
XP_036020303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146057.2NP_001139529.2  cytosolic acyl coenzyme A thioester hydrolase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL611985, AL671869, AL772240
    Consensus CDS
    CCDS51391.2
    UniProtKB/Swiss-Prot
    A2A8K9, A2A8L0, A2A8L2, Q3U8C6, Q59HQ2, Q91V12
    UniProtKB/TrEMBL
    E9PYH2
    Related
    ENSMUSP00000030779.4, ENSMUST00000030779.10
    Conserved Domains (2) summary
    cd03442
    Location:223346
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:183208
    NINJA_B; Putative nuclear localization signal
  2. NM_001146058.1NP_001139530.1  cytosolic acyl coenzyme A thioester hydrolase isoform 3

    See identical proteins and their annotated locations for NP_001139530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (3) with a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK152277, BQ748599, CX225643, CX235974
    Consensus CDS
    CCDS51392.1
    UniProtKB/TrEMBL
    E9PYH2
    Related
    ENSMUSP00000101277.3, ENSMUST00000105652.3
    Conserved Domains (2) summary
    cd03442
    Location:192315
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:152177
    NINJA_B; Putative nuclear localization signal
  3. NM_001369273.1NP_001356202.1  cytosolic acyl coenzyme A thioester hydrolase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL611985, AL671869, AL772240
    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (2) summary
    cd03442
    Location:180305
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:140165
    NINJA_B; Putative nuclear localization signal
  4. NM_001369274.1NP_001356203.1  cytosolic acyl coenzyme A thioester hydrolase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL611985, AL671869, AL772240
    Conserved Domains (2) summary
    cd03442
    Location:180303
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:140165
    NINJA_B; Putative nuclear localization signal
  5. NM_001369275.1NP_001356204.1  cytosolic acyl coenzyme A thioester hydrolase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL611985, AL671869, AL772240
    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (2) summary
    cd03442
    Location:165288
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:125150
    NINJA_B; Putative nuclear localization signal
  6. NM_001369276.1NP_001356205.1  cytosolic acyl coenzyme A thioester hydrolase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL611985, AL671869, AL772240
    Conserved Domains (2) summary
    cd03442
    Location:16121
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:140165
    NINJA_B; Putative nuclear localization signal
  7. NM_133348.2NP_579926.2  cytosolic acyl coenzyme A thioester hydrolase isoform 2

    See identical proteins and their annotated locations for NP_579926.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK152277, BQ748599, CA463703, CX235974
    Consensus CDS
    CCDS51390.1
    UniProtKB/TrEMBL
    E9PYH2
    Related
    ENSMUSP00000074827.4, ENSMUST00000075363.10
    Conserved Domains (2) summary
    cd03442
    Location:221344
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:181206
    NINJA_B; Putative nuclear localization signal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152258872..152356312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164410.1XP_036020303.1  cytosolic acyl coenzyme A thioester hydrolase isoform X2

    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (1) summary
    cd03442
    Location:163286
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  2. XM_030253767.2XP_030109627.1  cytosolic acyl coenzyme A thioester hydrolase isoform X1

    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (1) summary
    cd03442
    Location:171294
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  3. XM_030253769.2XP_030109629.1  cytosolic acyl coenzyme A thioester hydrolase isoform X2

    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (1) summary
    cd03442
    Location:163286
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  4. XM_030253768.2XP_030109628.1  cytosolic acyl coenzyme A thioester hydrolase isoform X2

    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (1) summary
    cd03442
    Location:163286
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  5. XM_006539169.2XP_006539232.1  cytosolic acyl coenzyme A thioester hydrolase isoform X2

    UniProtKB/TrEMBL
    E9PYH2
    Conserved Domains (1) summary
    cd03442
    Location:163286
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...