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ACOT7 acyl-CoA thioesterase 7 [ Homo sapiens (human) ]

Gene ID: 11332, updated on 21-Dec-2019

Summary

Official Symbol
ACOT7provided by HGNC
Official Full Name
acyl-CoA thioesterase 7provided by HGNC
Primary source
HGNC:HGNC:24157
See related
Ensembl:ENSG00000097021 MIM:602587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II
Summary
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues See more
Orthologs

Genomic context

See ACOT7 in Genome Data Viewer
Location:
1p36.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6264272..6393766, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6324332..6453826, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 153 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene hes family bHLH transcription factor 2 Neighboring gene microRNA 4252 Neighboring gene espin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty-acyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
medium-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
medium-chain fatty-acyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
palmitic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytosolic acyl coenzyme A thioester hydrolase
Names
CTE-IIa
acyl-CoA thioesterase 2
acyl-CoA thioesterase, long chain
brain acyl-CoA hydrolase
long chain acyl-CoA thioester hydrolase
NP_009205.3
NP_863654.1
NP_863655.1
NP_863656.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007274.3NP_009205.3  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa

    See identical proteins and their annotated locations for NP_009205.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHa) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHa that has a shorter and distinct N-terminus lacking a mitochondrial targetting sequence, compared to isoform hBACHb.
    Source sequence(s)
    AL031847, AL031848, BC017365, BG332214
    Consensus CDS
    CCDS30573.1
    UniProtKB/Swiss-Prot
    O00154
    Related
    ENSP00000439218.2, ENST00000545482.5
    Conserved Domains (1) summary
    cd03442
    Location:212335
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  2. NM_181864.3NP_863654.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb

    See identical proteins and their annotated locations for NP_863654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHb) encodes the longest isoform (hBACHb), which may be targetted to the mitochondria.
    Source sequence(s)
    AL031847, AL031848, BC017365, BM807217
    Consensus CDS
    CCDS65.1
    UniProtKB/Swiss-Prot
    O00154
    Related
    ENSP00000367086.2, ENST00000377855.6
    Conserved Domains (2) summary
    cd03442
    Location:222345
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:185207
    NINJA_B; Putative nuclear localization signal
  3. NM_181865.3NP_863655.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc

    See identical proteins and their annotated locations for NP_863655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHc) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHc that has a shorter and distinct N-terminus, compared to isoform hBACHb, and may also be targetted to the mitochondria.
    Source sequence(s)
    AB074418, AL031848, BC017365, BU594651
    Consensus CDS
    CCDS66.1
    UniProtKB/Swiss-Prot
    O00154
    Related
    ENSP00000367076.3, ENST00000377845.7
    Conserved Domains (1) summary
    cd03442
    Location:192315
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  4. NM_181866.3NP_863656.1  cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd

    See identical proteins and their annotated locations for NP_863656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (hBACHd) differs in the 5' UTR and 5' coding region, compared to variant hBACHb. It encodes isoform hBACHd that has a shorter and distinct N-terminus lacking a mitochondrial targetting sequence, compared to isoform hBACHb.
    Source sequence(s)
    AB074419, BC017365, BQ067921
    Consensus CDS
    CCDS67.1
    UniProtKB/Swiss-Prot
    O00154
    Related
    ENSP00000367073.3, ENST00000377842.7
    Conserved Domains (2) summary
    cd03442
    Location:171294
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    pfam16136
    Location:134156
    NINJA_B; Putative nuclear localization signal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    6264272..6393766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181862.2: Suppressed sequence

    Description
    NM_181862.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_181863.2: Suppressed sequence

    Description
    NM_181863.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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