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Nkiras1 NFKB inhibitor interacting Ras-like protein 1 [ Mus musculus (house mouse) ]

Gene ID: 69721, updated on 24-Jan-2023

Summary

Official Symbol
Nkiras1provided by MGI
Official Full Name
NFKB inhibitor interacting Ras-like protein 1provided by MGI
Primary source
MGI:MGI:1916971
See related
Ensembl:ENSMUSG00000021772 AllianceGenome:MGI:1916971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBRAS1; kappaB-Ras1; 2400004O09Rik
Summary
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 13.7), cerebellum adult (RPKM 13.3) and 21 other tissues See more
Orthologs
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Genomic context

See Nkiras1 in Genome Data Viewer
Location:
14; 14 A1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4185693..4198560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18271136..18284003)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22350 Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene predicted gene, 41098 Neighboring gene ribosomal protein L15 Neighboring gene predicted gene 7084

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 1
Names
I-kappa-B-interacting Ras-like protein 1
kappa B-Ras protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316711.1NP_001303640.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154489, AK010285, AK028539, AW490494, BC054390, BY332128
    UniProtKB/Swiss-Prot
    Q8CEC5
    Conserved Domains (1) summary
    cl38936
    Location:8138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001316712.1NP_001303641.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154489, AK028539, AW490494, BC054390, BY114837, BY332128
    UniProtKB/Swiss-Prot
    Q8CEC5
    Conserved Domains (1) summary
    cl21455
    Location:12142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_023526.4NP_076015.2  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_076015.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154489, AK028539, AW490494, BC054390, BY332128
    Consensus CDS
    CCDS26836.1
    UniProtKB/Swiss-Prot
    Q8CEC5, Q9JKV3
    UniProtKB/TrEMBL
    A0A6P5R130
    Related
    ENSMUSP00000121496.2, ENSMUST00000132374.9
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    4185693..4198560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247999.1XP_030103859.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:8138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_036158841.1XP_036014734.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:8138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_006518097.5XP_006518160.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006518160.1

    UniProtKB/Swiss-Prot
    Q8CEC5, Q9JKV3
    UniProtKB/TrEMBL
    A0A6P5R130
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases