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Nkiras1 NFKB inhibitor interacting Ras-like protein 1 [ Mus musculus (house mouse) ]

Gene ID: 69721, updated on 17-Aug-2024

Summary

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Official Symbol
Nkiras1provided by MGI
Official Full Name
NFKB inhibitor interacting Ras-like protein 1provided by MGI
Primary source
MGI:MGI:1916971
See related
Ensembl:ENSMUSG00000021772 AllianceGenome:MGI:1916971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBRAS1; kappaB-Ras1; 2400004O09Rik
Summary
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 13.7), cerebellum adult (RPKM 13.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 7.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4185693..4198560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18271136..18284003)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22350 Neighboring gene STARR-seq mESC enhancer starr_36051 Neighboring gene STARR-seq mESC enhancer starr_36050 Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene predicted gene, 41098 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:19103554-19103663 Neighboring gene ribosomal protein L15 Neighboring gene predicted gene 7084

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Beel S, et al. Nat Commun, 2020 Jul 8. PMID 32641778, Free PMC Article
  2. Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes. Yang Y, et al. Nat Biotechnol, 2003 Apr. PMID 12627171
  3. RelA/p65 regulation of IkappaBbeta. Hertlein E, et al. Mol Cell Biol, 2005 Jun. PMID 15923614, Free PMC Article
  4. A subclass of Ras proteins that regulate the degradation of IkappaB. Fenwick C, et al. Science, 2000 Feb 4. PMID 10657303
  5. κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. Oeckinghaus A, et al. Cell Rep, 2014 Sep 25. PMID 25220458, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ral protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ral protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lung alveolus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within surfactant homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 1
Names
I-kappa-B-interacting Ras-like protein 1
kappa B-Ras protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316711.1 → NP_001303640.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154489, AK010285, AK028539, AW490494, BC054390, BY332128
    UniProtKB/Swiss-Prot
    Q8CEC5
    Conserved Domains (1) summary
    cl38936
    Location:8 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001316712.1 → NP_001303641.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154489, AK028539, AW490494, BC054390, BY114837, BY332128
    UniProtKB/Swiss-Prot
    Q8CEC5
    Conserved Domains (1) summary
    cl21455
    Location:12 → 142
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_023526.4 → NP_076015.2  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_076015.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154489, AK028539, AW490494, BC054390, BY332128
    Consensus CDS
    CCDS26836.1
    UniProtKB/Swiss-Prot
    Q8CEC5, Q9JKV3
    Related
    ENSMUSP00000121496.2, ENSMUST00000132374.9
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    4185693..4198560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247999.1 → XP_030103859.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:8 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_036158841.1 → XP_036014734.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:8 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006518097.5 → XP_006518160.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006518160.1

    UniProtKB/Swiss-Prot
    Q8CEC5, Q9JKV3
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEC5.1 GenPept UniProtKB/Swiss-Prot:Q8CEC5

Gene LinkOut

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