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NKIRAS1 NFKB inhibitor interacting Ras like 1 [ Homo sapiens (human) ]

Gene ID: 28512, updated on 26-Oct-2022

Summary

Official Symbol
NKIRAS1provided by HGNC
Official Full Name
NFKB inhibitor interacting Ras like 1provided by HGNC
Primary source
HGNC:HGNC:17899
See related
Ensembl:ENSG00000197885 MIM:604496; AllianceGenome:HGNC:17899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KBRAS1; kappaB-Ras1
Summary
Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 15.3), testis (RPKM 11.7) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See NKIRAS1 in Genome Data Viewer
Location:
3p24.2
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23889951..23946562, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23894728..23951314, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23931442..23988053, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 4 Neighboring gene ribosomal protein L15 Neighboring gene uncharacterized LOC124909354 Neighboring gene Sharpr-MPRA regulatory region 12700 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene Sharpr-MPRA regulatory region 5785

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in Ral protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in surfactant homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 1
Names
I-kappa-B-interacting Ras-like protein 1
NFKB inhibitor interacting Ras-like protein 1
kappa B-Ras protein 1
kappa B-ras 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377351.1NP_001364280.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914, DA116722
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Related
    ENSP00000394214.2, ENST00000416026.2
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001377352.1NP_001364281.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001377353.1NP_001364282.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Related
    ENSP00000373411.3, ENST00000388759.7
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001377354.1NP_001364283.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001377355.1NP_001364284.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_001377356.1NP_001364285.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. NM_001377357.1NP_001364286.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. NM_001377358.1NP_001364287.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. NM_001377359.1NP_001364288.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. NM_001377360.1NP_001364289.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. NM_001377361.1NP_001364290.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  12. NM_001377362.1NP_001364291.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. NM_001377363.1NP_001364292.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Related
    ENSP00000483749.1, ENST00000614374.4
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  14. NM_001377364.1NP_001364293.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  15. NM_001377365.1NP_001364294.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  16. NM_001377366.1NP_001364295.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  17. NM_001377367.1NP_001364296.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  18. NM_001377368.1NP_001364297.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  19. NM_001377369.1NP_001364298.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6111
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  20. NM_001377370.1NP_001364299.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  21. NM_001377371.1NP_001364300.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  22. NM_001377372.1NP_001364301.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  23. NM_001377380.1NP_001364309.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18
    Related
    ENSP00000392307.2, ENST00000421515.6
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  24. NM_020345.4NP_065078.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065078.1

    Status: VALIDATED

    Source sequence(s)
    AC124914, BC012145, BG713995
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000400385.2, ENST00000425478.7
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    23889951..23946562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447998.1XP_047303954.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18
  2. XM_047447999.1XP_047303955.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18
  3. XM_024453460.2XP_024309228.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18
    Related
    ENSP00000393785.2, ENST00000443659.6
    Conserved Domains (1) summary
    cl38936
    Location:6168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    23894728..23951314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)