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Mrln myoregulin [ Mus musculus (house mouse) ]

Gene ID: 69563, updated on 12-May-2024

Summary

Official Symbol
Mrlnprovided by MGI
Official Full Name
myoregulinprovided by MGI
Primary source
MGI:MGI:1916813
See related
Ensembl:ENSMUSG00000019933 AllianceGenome:MGI:1916813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mln; Linc-RAM; 2310015B20Rik
Summary
This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. [provided by RefSeq, Feb 2015]
Expression
Biased expression in limb E14.5 (RPKM 6.8), mammary gland adult (RPKM 3.4) and 7 other tissues See more
Orthologs
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Genomic context

See Mrln in Genome Data Viewer
Location:
10 B5.3; 10 36.68 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (70040494..70055541)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (70204664..70219711)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin 3, epithelial Neighboring gene predicted gene, 33361 Neighboring gene STARR-seq mESC enhancer starr_27068 Neighboring gene STARR-seq mESC enhancer starr_27069 Neighboring gene STARR-positive B cell enhancer ABC_E5146 Neighboring gene STARR-seq mESC enhancer starr_27073 Neighboring gene predicted gene, 51771 Neighboring gene coiled-coil domain containing 6 Neighboring gene uncharacterized LOC118567787 Neighboring gene STARR-seq mESC enhancer starr_27078 Neighboring gene STARR-seq mESC enhancer starr_27079 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 9 Neighboring gene predicted gene, 40687 Neighboring gene predicted gene, 33704

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304739.1NP_001291668.1  myoregulin

    See identical proteins and their annotated locations for NP_001291668.1

    Status: REVIEWED

    Source sequence(s)
    AC122923, AK009351, BY282836
    Consensus CDS
    CCDS88021.1
    UniProtKB/Swiss-Prot
    Q9CV60
    Related
    ENSMUSP00000150523.2, ENSMUST00000020090.8
    Conserved Domains (1) summary
    cd20260
    Location:246
    Myoregulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    70040494..70055541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314076.2XP_017169565.1  myoregulin isoform X1

    UniProtKB/Swiss-Prot
    Q9CV60
    Conserved Domains (1) summary
    cd20260
    Location:246
    Myoregulin