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MRLN myoregulin [ Homo sapiens (human) ]

Gene ID: 100507027, updated on 23-Nov-2021

Summary

Official Symbol
MRLNprovided by HGNC
Official Full Name
myoregulinprovided by HGNC
Primary source
HGNC:HGNC:48649
See related
Ensembl:ENSG00000227877 MIM:616246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M1; MLN; MUSER1; Linc-RAM; LINC00948
Summary
This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]
Expression
Biased expression in kidney (RPKM 2.5), prostate (RPKM 1.2) and 3 other tissues See more
Orthologs
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Genomic context

See MRLN in Genome Data Viewer
Location:
10q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (59736692..59753455, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61496450..61513213, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378319 Neighboring gene solute carrier family 16 member 9 Neighboring gene coiled-coil domain containing 6 Neighboring gene Sharpr-MPRA regulatory region 3861 Neighboring gene long intergenic non-protein coding RNA 1553

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myoregulin
Names
Linc-RNA activator of myogenesis
long intergenic non-protein coding RNA 948
muscle enriched RNA 1
muscle specific 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304731.2NP_001291660.1  myoregulin

    See identical proteins and their annotated locations for NP_001291660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB019391, AC022027, BG210823
    Consensus CDS
    CCDS81467.1
    UniProtKB/Swiss-Prot
    P0DMT0
    Related
    ENSP00000488748.1, ENST00000414264.6
    Conserved Domains (1) summary
    cd20260
    Location:246
    Myoregulin
  2. NM_001304732.2NP_001291661.1  myoregulin

    See identical proteins and their annotated locations for NP_001291661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB019391, AC022027, BG210823, BM021470
    Consensus CDS
    CCDS81467.1
    UniProtKB/Swiss-Prot
    P0DMT0
    Related
    ENSP00000488299.1, ENST00000430431.5
    Conserved Domains (1) summary
    cd20260
    Location:246
    Myoregulin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    59736692..59753455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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