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BTG1 BTG anti-proliferation factor 1 [ Homo sapiens (human) ]

Gene ID: 694, updated on 22-Sep-2022

Summary

Official Symbol
BTG1provided by HGNC
Official Full Name
BTG anti-proliferation factor 1provided by HGNC
Primary source
HGNC:HGNC:1130
See related
Ensembl:ENSG00000133639 MIM:109580; AllianceGenome:HGNC:1130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APRO2
Summary
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 117.9), lymph node (RPKM 72.6) and 25 other tissues See more
Orthologs
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Genomic context

See BTG1 in Genome Data Viewer
Location:
12q21.33
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (92140278..92145846, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (92117840..92123409, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (92534054..92539622, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1619 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:92471461-92472660 Neighboring gene Sharpr-MPRA regulatory region 10753 Neighboring gene BTG1 divergent transcript Neighboring gene ribosomal protein L21 pseudogene 106 Neighboring gene long intergenic non-protein coding RNA 2391 Neighboring gene uncharacterized LOC105369902

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
protein BTG1
Names
B-cell translocation gene 1 protein
B-cell translocation gene 1, anti-proliferative

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065368.1 RefSeqGene

    Range
    5001..10569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1424

mRNA and Protein(s)

  1. NM_001731.3NP_001722.1  protein BTG1

    See identical proteins and their annotated locations for NP_001722.1

    Status: REVIEWED

    Source sequence(s)
    AC025164, AK313309, BC009050, BC064953, X61123
    Consensus CDS
    CCDS9043.1
    UniProtKB/Swiss-Prot
    P31607, P62324
    UniProtKB/TrEMBL
    Q6IBC8
    Related
    ENSP00000256015.3, ENST00000256015.5
    Conserved Domains (1) summary
    smart00099
    Location:11118
    btg1; tob/btg1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    92140278..92145846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    92117840..92123409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)