U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pacrg PARK2 co-regulated [ Mus musculus (house mouse) ]

Gene ID: 69310, updated on 1-Mar-2024

Summary

Official Symbol
Pacrgprovided by MGI
Official Full Name
PARK2 co-regulatedprovided by MGI
Primary source
MGI:MGI:1916560
See related
Ensembl:ENSMUSG00000037196 AllianceGenome:MGI:1916560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700008H23Rik
Summary
Enables ubiquitin protein ligase binding activity. Involved in negative regulation of cell death. Acts upstream of or within cellular protein localization and spermatid development. Located in several cellular components, including cell body; manchette; and sperm midpiece. Is expressed in brain; pancreas trunk epithelium; and spinal cord ventricular layer. Orthologous to human PACRG (parkin coregulated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 92.0) and frontal lobe adult (RPKM 3.8) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pacrg in Genome Data Viewer
Location:
17 A1; 17 7.8 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (10621938..11059078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (10403009..10840191, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700110C19 gene Neighboring gene VISTA enhancer mm1488 Neighboring gene STARR-seq mESC enhancer starr_41803 Neighboring gene STARR-seq mESC enhancer starr_41817 Neighboring gene RIKEN cDNA A230009B12 gene Neighboring gene STARR-seq mESC enhancer starr_41818 Neighboring gene predicted gene, 39565 Neighboring gene STARR-seq mESC enhancer starr_41819 Neighboring gene predicted gene, 52294 Neighboring gene predicted gene, 53987 Neighboring gene STARR-seq mESC enhancer starr_41822 Neighboring gene STARR-seq mESC enhancer starr_41823 Neighboring gene predicted gene 16168 Neighboring gene STARR-seq mESC enhancer starr_41825 Neighboring gene STARR-seq mESC enhancer starr_41826 Neighboring gene STARR-seq mESC enhancer starr_41827 Neighboring gene predicted gene 16169 Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene uncharacterized protein C3orf18 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_41829 Neighboring gene predicted gene, 41526

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axonemal B tubule inner sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in manchette IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
parkin coregulated gene protein homolog
Names
PARK2 coregulated gene protein
hypertension-related protein 1-like protein
parkin co-regulated gene protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027032.2NP_081308.1  parkin coregulated gene protein homolog

    See identical proteins and their annotated locations for NP_081308.1

    Status: VALIDATED

    Source sequence(s)
    AK005771, AK135510
    Consensus CDS
    CCDS28388.1
    UniProtKB/Swiss-Prot
    Q7TPF9, Q8CG20, Q9DAK2
    UniProtKB/TrEMBL
    Q0VB91, Q3UXK4
    Related
    ENSMUSP00000044376.7, ENSMUST00000041463.7
    Conserved Domains (2) summary
    pfam10274
    Location:54237
    ParcG; Parkin co-regulated protein
    cl21467
    Location:1954
    Cytochrom_C; Cytochrome c

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    10621938..11059078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523353.4XP_006523416.1  parkin coregulated gene protein homolog isoform X1

    See identical proteins and their annotated locations for XP_006523416.1

    Conserved Domains (1) summary
    pfam10274
    Location:1135
    ParcG; Parkin co-regulated protein