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PACRG parkin coregulated [ Homo sapiens (human) ]

Gene ID: 135138, updated on 15-Jun-2019

Summary

Official Symbol
PACRGprovided by HGNC
Official Full Name
parkin coregulatedprovided by HGNC
Primary source
HGNC:HGNC:19152
See related
Ensembl:ENSG00000112530 MIM:608427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUP; PACRG2.1; PARK2CRG; HAK005771
Summary
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See PACRG in Genome Data Viewer
Location:
6q26
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (162726870..163315492)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (163148164..163736524)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC105369171 Neighboring gene keratin 8 pseudogene 44 Neighboring gene tRNA-Glu (TTC) 15-1 Neighboring gene VISTA enhancer hs1358 Neighboring gene ribosomal protein L34 pseudogene 15 Neighboring gene PACRG antisense RNA 2 Neighboring gene uncharacterized LOC105378095 Neighboring gene PACRG antisense RNA 3 Neighboring gene uncharacterized LOC401282 Neighboring gene PACRG antisense RNA 1 Neighboring gene ribosomal protein L37a pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
sperm midpiece IEA
Inferred from Electronic Annotation
more info
 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
parkin coregulated gene protein
Names
PARK2 co-regulated
PARK2 coregulated
molecular chaperone/chaperonin-binding protein
parkin co-regulated gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011525.1 RefSeqGene

    Range
    5001..593361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080378.1NP_001073847.1  parkin coregulated gene protein isoform 2

    See identical proteins and their annotated locations for NP_001073847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AP001576, BC044227
    Consensus CDS
    CCDS43524.1
    UniProtKB/Swiss-Prot
    Q96M98
    Related
    ENSP00000355855.2, ENST00000366889.6
    Conserved Domains (1) summary
    pfam10274
    Location:70253
    ParcG; Parkin co-regulated protein
  2. NM_001080379.1NP_001073848.1  parkin coregulated gene protein isoform 2

    See identical proteins and their annotated locations for NP_001073848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon at its 5' end and an in-frame internal exon, compared to variant 1. These differences produce a unique 5' UTR and a protein (isoform 2) that is shorter than isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AF546872, BC044227
    Consensus CDS
    CCDS43524.1
    UniProtKB/Swiss-Prot
    Q96M98
    Related
    ENSP00000355854.2, ENST00000366888.6
    Conserved Domains (1) summary
    pfam10274
    Location:70253
    ParcG; Parkin co-regulated protein
  3. NM_152410.2NP_689623.2  parkin coregulated gene protein isoform 1

    See identical proteins and their annotated locations for NP_689623.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK057286, AL354942, BC044227
    Consensus CDS
    CCDS5284.1
    UniProtKB/Swiss-Prot
    Q96M98
    Related
    ENSP00000337946.3, ENST00000337019.7
    Conserved Domains (1) summary
    pfam10274
    Location:70292
    ParcG; Parkin co-regulated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    162726870..163315492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010277.2XP_016865766.1  parkin coregulated gene protein isoform X1

  2. XM_017010275.2XP_016865764.1  parkin coregulated gene protein isoform X1

  3. XM_017010279.2XP_016865768.1  parkin coregulated gene protein isoform X1

  4. XM_017010278.2XP_016865767.1  parkin coregulated gene protein isoform X1

  5. XM_017010276.2XP_016865765.1  parkin coregulated gene protein isoform X1

  6. XM_011535468.3XP_011533770.1  parkin coregulated gene protein isoform X11

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  7. XM_006715344.4XP_006715407.1  parkin coregulated gene protein isoform X5

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  8. XM_006715345.4XP_006715408.1  parkin coregulated gene protein isoform X9

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  9. XM_011535469.3XP_011533771.1  parkin coregulated gene protein isoform X12

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  10. XM_005266826.5XP_005266883.1  parkin coregulated gene protein isoform X10

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  11. XM_005266825.5XP_005266882.1  parkin coregulated gene protein isoform X7

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  12. XM_017010280.2XP_016865769.1  parkin coregulated gene protein isoform X4

  13. XM_011535466.2XP_011533768.1  parkin coregulated gene protein isoform X8

    Conserved Domains (1) summary
    pfam10274
    Location:70204
    ParcG; Parkin co-regulated protein
  14. XM_011535462.3XP_011533764.1  parkin coregulated gene protein isoform X3

    Conserved Domains (1) summary
    pfam10274
    Location:70205
    ParcG; Parkin co-regulated protein
  15. XM_011535461.3XP_011533763.1  parkin coregulated gene protein isoform X2

    Conserved Domains (1) summary
    pfam10274
    Location:70227
    ParcG; Parkin co-regulated protein
  16. XM_011535471.2XP_011533773.1  parkin coregulated gene protein isoform X13

    Conserved Domains (1) summary
    pfam10274
    Location:7097
    ParcG; Parkin co-regulated protein
  17. XM_017010281.2XP_016865770.1  parkin coregulated gene protein isoform X6

  18. XM_017010282.2XP_016865771.1  parkin coregulated gene protein isoform X6

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