U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TCF3 transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 6929, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TCF3provided by HGNC
Official Full Name
transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:11633
See related
Ensembl:ENSG00000071564 MIM:147141; AllianceGenome:HGNC:11633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21
Summary
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 16.2), lymph node (RPKM 12.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TCF3 in Genome Data Viewer
Location:
19p13.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1609292..1652615, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1580117..1623781, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1609291..1652614, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584307-1584918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584919-1585529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1590888-1591877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13615 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1606417-1607038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13618 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit XI Neighboring gene RNA, U6 small nuclear 1223, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1626353-1626854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1649155-1649654 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1651633-1651855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9740 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13623 Neighboring gene MPRA-validated peak3223 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1667070-1667570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1668943-1669693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1672373-1672900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690448-1690998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690999-1691550 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1722988-1723177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1725449-1725948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1743285-1743784 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1743951-1744173 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:1747113-1748312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1748390-1748908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757201-1757790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757791-1758378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1762447-1762983 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1765801-1766322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1767617-1768311 Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1789295-1790117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1795609-1796421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1796422-1797233 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1799861-1800031 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene MPRA-validated peak3225 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1811783-1812528

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors. Zhang X, et al. Leukemia, 2012 Dec. PMID 22743623
  2. Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. Steininger A, et al. J Exp Med, 2011 Aug 1. PMID 21788410, Free PMC Article
  3. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Schwartz R, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16782810, Free PMC Article
  4. Overexpression of transcription factor 3 drives hepatocarcinoma development by enhancing cell proliferation via activating Wnt signaling pathway. Pu XY, et al. Hepatobiliary Pancreat Dis Int, 2022 Aug. PMID 35033448
  5. Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors. Mehmood R, et al. Mol Biol Cell, 2011 Oct. PMID 21832153, Free PMC Article

See all (294) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Embryonic stem cell related gene regulates alternative splicing of transcription factor 3 to maintain human embryonic stem cells' self-renewal and pluripotency.
    Title: Embryonic stem cell related gene regulates alternative splicing of transcription factor 3 to maintain human embryonic stem cells' self-renewal and pluripotency.
  2. Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.
    Title: Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.
  3. Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
    Title: Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
  4. Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
    Title: Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
  5. E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
    Title: E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
  6. TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
    Title: TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
  7. Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
    Title: Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
  8. Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.
    Title: Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.
  9. Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
    Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
  10. Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.
    Title: Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (136)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Agammaglobulinemia 8, autosomal dominant
MedGen: C4310786 OMIM: 616941 GeneReviews: Not available
Compare labs
Agammaglobulinemia 8b, autosomal recessive
MedGen: C5676958 OMIM: 619824 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC129647, MGC129648

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to E-box binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IC
Inferred by Curator
more info
 PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables vitamin D response element binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in B cell lineage commitment IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in B cell lineage commitment NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in immunoglobulin V(D)J recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immunoglobulin V(D)J recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription factor E2-alpha
Names
E2A-HLF fusion transcript protein
NOL1-TCF3 fusion
VDR interacting repressor
class B basic helix-loop-helix protein 21
helix-loop-helix protein HE47
immunoglobulin transcription factor 1
kappa-E2-binding factor
negative vitamin D response element-binding protein
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
transcription factor ITF-1
vitamin D receptor-interacting repressor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029953.2 RefSeqGene

    Range
    4932..48255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1325

mRNA and Protein(s)

  1. NM_001136139.4 → NP_001129611.1  transcription factor E2-alpha isoform E47

    See identical proteins and their annotated locations for NP_001129611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, lacks an exon and includes an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).
    Source sequence(s)
    AC005321, AC006274, AW028755, BG284440, BU528547, CD516687, CD674814, KC877695, M24404
    Consensus CDS
    CCDS45899.1
    UniProtKB/TrEMBL
    X6REB3
    Related
    ENSP00000468487.1, ENST00000588136.7
    Conserved Domains (1) summary
    cd18943
    Location:538 → 611
    bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins

  2. NM_001351778.2 → NP_001338707.1  transcription factor E2-alpha isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and contains an alternate splice structure in the 3' region, resulting in differences in the 3' UTR. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
    Source sequence(s)
    AA251176, AC006274, AW968445, KC877695, M31222
    UniProtKB/TrEMBL
    Q6PJU3
    Conserved Domains (2) summary
    smart00353
    Location:554 → 607
    HLH; helix loop helix domain
    pfam03985
    Location:495 → 549
    Paf1; Paf1

  3. NM_001351779.2 → NP_001338708.1  transcription factor E2-alpha isoform E47

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate penultimate exon compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).
    Source sequence(s)
    AC005321, AC006274, AW028755, BG284440, KC877695, M24404, M31222
    Consensus CDS
    CCDS45899.1
    UniProtKB/TrEMBL
    X6REB3
    Conserved Domains (1) summary
    cd18943
    Location:538 → 611
    bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins

  4. NM_003200.5 → NP_003191.1  transcription factor E2-alpha isoform E12

    See identical proteins and their annotated locations for NP_003191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (E12). This isoform is also known as Pan-2.
    Source sequence(s)
    AC005321, AC006274, KC877695, M31222
    Consensus CDS
    CCDS12074.1
    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
    UniProtKB/TrEMBL
    Q6PJU3
    Related
    ENSP00000262965.5, ENST00000262965.12
    Conserved Domains (2) summary
    smart00353
    Location:555 → 608
    HLH; helix loop helix domain
    pfam03985
    Location:496 → 549
    Paf1; Paf1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1609292..1652615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439298.1 → XP_047295254.1  transcription factor E2-alpha isoform X12

  2. XM_047439297.1 → XP_047295253.1  transcription factor E2-alpha isoform X10

  3. XM_047439296.1 → XP_047295252.1  transcription factor E2-alpha isoform X11

    Related
    ENSP00000378813.3, ENST00000395423.7

  4. XM_047439294.1 → XP_047295250.1  transcription factor E2-alpha isoform X11

  5. XM_047439290.1 → XP_047295246.1  transcription factor E2-alpha isoform X9

  6. XM_047439286.1 → XP_047295242.1  transcription factor E2-alpha isoform X8

  7. XM_011528226.3 → XP_011526528.1  transcription factor E2-alpha isoform X8

    UniProtKB/TrEMBL
    X6REB3
    Conserved Domains (1) summary
    smart00353
    Location:551 → 604
    HLH; helix loop helix domain

  8. XM_047439279.1 → XP_047295235.1  transcription factor E2-alpha isoform X5

  9. XM_047439285.1 → XP_047295241.1  transcription factor E2-alpha isoform X7

  10. XM_011528225.3 → XP_011526527.1  transcription factor E2-alpha isoform X7

    UniProtKB/TrEMBL
    X6REB3
    Conserved Domains (1) summary
    smart00353
    Location:551 → 604
    HLH; helix loop helix domain

  11. XM_047439284.1 → XP_047295240.1  transcription factor E2-alpha isoform X6

  12. XM_047439283.1 → XP_047295239.1  transcription factor E2-alpha isoform X6

  13. XM_047439278.1 → XP_047295234.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  14. XM_047439277.1 → XP_047295233.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  15. XM_017027181.2 → XP_016882670.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
    UniProtKB/TrEMBL
    Q6PJU3
    Conserved Domains (2) summary
    smart00353
    Location:555 → 608
    HLH; helix loop helix domain
    pfam03985
    Location:496 → 549
    Paf1; Paf1

  16. XM_047439261.1 → XP_047295217.1  transcription factor E2-alpha isoform X2

  17. XM_017027178.2 → XP_016882667.1  transcription factor E2-alpha isoform X3

    UniProtKB/TrEMBL
    X6REB3
    Conserved Domains (1) summary
    smart00353
    Location:581 → 634
    HLH; helix loop helix domain

  18. XM_047439262.1 → XP_047295218.1  transcription factor E2-alpha isoform X3

    Related
    ENSP00000396363.3, ENST00000453954.6

  19. XM_006722855.5 → XP_006722918.1  transcription factor E2-alpha isoform X3

    See identical proteins and their annotated locations for XP_006722918.1

    UniProtKB/TrEMBL
    X6REB3
    Conserved Domains (1) summary
    smart00353
    Location:581 → 634
    HLH; helix loop helix domain

  20. XM_047439259.1 → XP_047295215.1  transcription factor E2-alpha isoform X1

  21. XM_047439260.1 → XP_047295216.1  transcription factor E2-alpha isoform X1

  22. XM_047439295.1 → XP_047295251.1  transcription factor E2-alpha isoform X11

  23. XM_047439291.1 → XP_047295247.1  transcription factor E2-alpha isoform X9

  24. XM_047439280.1 → XP_047295236.1  transcription factor E2-alpha isoform X5

  25. XM_047439289.1 → XP_047295245.1  transcription factor E2-alpha isoform X7

  26. XM_047439287.1 → XP_047295243.1  transcription factor E2-alpha isoform X7

  27. XM_047439282.1 → XP_047295238.1  transcription factor E2-alpha isoform X6

  28. XM_047439281.1 → XP_047295237.1  transcription factor E2-alpha isoform X6

  29. XM_047439276.1 → XP_047295232.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  30. XM_047439258.1 → XP_047295214.1  transcription factor E2-alpha isoform X1

  31. XM_047439293.1 → XP_047295249.1  transcription factor E2-alpha isoform X10

  32. XM_047439292.1 → XP_047295248.1  transcription factor E2-alpha isoform X10

  33. XM_047439275.1 → XP_047295231.1  transcription factor E2-alpha isoform X9

  34. XM_047439274.1 → XP_047295230.1  transcription factor E2-alpha isoform X8

  35. XM_047439273.1 → XP_047295229.1  transcription factor E2-alpha isoform X8

  36. XM_047439271.1 → XP_047295227.1  transcription factor E2-alpha isoform X8

  37. XM_047439267.1 → XP_047295223.1  transcription factor E2-alpha isoform X5

  38. XM_047439266.1 → XP_047295222.1  transcription factor E2-alpha isoform X5

  39. XM_047439288.1 → XP_047295244.1  transcription factor E2-alpha isoform X7

  40. XM_047439272.1 → XP_047295228.1  transcription factor E2-alpha isoform X7

  41. XM_047439270.1 → XP_047295226.1  transcription factor E2-alpha isoform X7

  42. XM_047439269.1 → XP_047295225.1  transcription factor E2-alpha isoform X6

  43. XM_047439268.1 → XP_047295224.1  transcription factor E2-alpha isoform X6

  44. XM_047439265.1 → XP_047295221.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  45. XM_047439264.1 → XP_047295220.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  46. XM_047439263.1 → XP_047295219.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1580117..1623781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321896.1 → XP_054177871.1  transcription factor E2-alpha isoform X12

  2. XM_054321895.1 → XP_054177870.1  transcription factor E2-alpha isoform X10

  3. XM_054321894.1 → XP_054177869.1  transcription factor E2-alpha isoform X11

  4. XM_054321892.1 → XP_054177867.1  transcription factor E2-alpha isoform X11

  5. XM_054321888.1 → XP_054177863.1  transcription factor E2-alpha isoform X9

  6. XM_054321883.1 → XP_054177858.1  transcription factor E2-alpha isoform X8

  7. XM_054321880.1 → XP_054177855.1  transcription factor E2-alpha isoform X8

  8. XM_054321869.1 → XP_054177844.1  transcription factor E2-alpha isoform X5

  9. XM_054321882.1 → XP_054177857.1  transcription factor E2-alpha isoform X7

  10. XM_054321878.1 → XP_054177853.1  transcription factor E2-alpha isoform X7

  11. XM_054321877.1 → XP_054177852.1  transcription factor E2-alpha isoform X6

  12. XM_054321875.1 → XP_054177850.1  transcription factor E2-alpha isoform X6

  13. XM_054321868.1 → XP_054177843.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  14. XM_054321866.1 → XP_054177841.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  15. XM_054321864.1 → XP_054177839.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  16. XM_054321854.1 → XP_054177829.1  transcription factor E2-alpha isoform X2

  17. XM_054321856.1 → XP_054177831.1  transcription factor E2-alpha isoform X3

  18. XM_054321857.1 → XP_054177832.1  transcription factor E2-alpha isoform X3

  19. XM_054321855.1 → XP_054177830.1  transcription factor E2-alpha isoform X3

  20. XM_054321852.1 → XP_054177827.1  transcription factor E2-alpha isoform X1

  21. XM_054321853.1 → XP_054177828.1  transcription factor E2-alpha isoform X1

  22. XM_054321893.1 → XP_054177868.1  transcription factor E2-alpha isoform X11

  23. XM_054321889.1 → XP_054177864.1  transcription factor E2-alpha isoform X9

  24. XM_054321871.1 → XP_054177846.1  transcription factor E2-alpha isoform X5

  25. XM_054321887.1 → XP_054177862.1  transcription factor E2-alpha isoform X7

  26. XM_054321885.1 → XP_054177860.1  transcription factor E2-alpha isoform X7

  27. XM_054321873.1 → XP_054177848.1  transcription factor E2-alpha isoform X6

  28. XM_054321872.1 → XP_054177847.1  transcription factor E2-alpha isoform X6

  29. XM_054321862.1 → XP_054177837.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  30. XM_054321851.1 → XP_054177826.1  transcription factor E2-alpha isoform X1

  31. XM_054321886.1 → XP_054177861.1  transcription factor E2-alpha isoform X7

  32. XM_054321858.1 → XP_054177833.1  transcription factor E2-alpha isoform X5

  33. XM_054321870.1 → XP_054177845.1  transcription factor E2-alpha isoform X5

  34. XM_054321867.1 → XP_054177842.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  35. XM_054321865.1 → XP_054177840.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  36. XM_054321860.1 → XP_054177835.1  transcription factor E2-alpha isoform X8

  37. XM_054321884.1 → XP_054177859.1  transcription factor E2-alpha isoform X8

  38. XM_054321881.1 → XP_054177856.1  transcription factor E2-alpha isoform X7

  39. XM_054321861.1 → XP_054177836.1  transcription factor E2-alpha isoform X9

  40. XM_054321859.1 → XP_054177834.1  transcription factor E2-alpha isoform X8

  41. XM_054321879.1 → XP_054177854.1  transcription factor E2-alpha isoform X7

  42. XM_054321876.1 → XP_054177851.1  transcription factor E2-alpha isoform X6

  43. XM_054321874.1 → XP_054177849.1  transcription factor E2-alpha isoform X6

  44. XM_054321863.1 → XP_054177838.1  transcription factor E2-alpha isoform X4

    UniProtKB/Swiss-Prot
    P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9

  45. XM_054321891.1 → XP_054177866.1  transcription factor E2-alpha isoform X10

  46. XM_054321890.1 → XP_054177865.1  transcription factor E2-alpha isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15923.1 GenPept UniProtKB/Swiss-Prot:P15923

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous