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Comtd1 catechol-O-methyltransferase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69156, updated on 26-Sep-2022

Summary

Official Symbol
Comtd1provided by MGI
Official Full Name
catechol-O-methyltransferase domain containing 1provided by MGI
Primary source
MGI:MGI:1916406
See related
Ensembl:ENSMUSG00000021773 AllianceGenome:MGI:1916406
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT773; 1810030M08Rik
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to act upstream of or within methylation. Located in mitochondrion. Is expressed in alimentary system; liver; and nervous system. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 17.1), stomach adult (RPKM 16.9) and 28 other tissues See more
Orthologs
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Genomic context

See Comtd1 in Genome Data Viewer
Location:
14; 14 A3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21895929..21898978, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21845861..21848910, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 8 Neighboring gene predicted gene, 23502 Neighboring gene RIKEN cDNA A430057M04 gene Neighboring gene voltage-dependent anion channel 2 Neighboring gene RIKEN cDNA A330001L22 gene Neighboring gene zinc finger protein 503

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
catechol O-methyltransferase domain-containing protein 1
Names
O-methyltransferase-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026965.2NP_081241.1  catechol O-methyltransferase domain-containing protein 1

    See identical proteins and their annotated locations for NP_081241.1

    Status: PROVISIONAL

    Source sequence(s)
    AK054334
    Consensus CDS
    CCDS26868.1
    UniProtKB/Swiss-Prot
    Q8BIG7
    UniProtKB/TrEMBL
    A0A6P5R0K6, A0A8C6GL18
    Related
    ENSMUSP00000119330.2, ENSMUST00000124549.9
    Conserved Domains (1) summary
    cl17173
    Location:60261
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21895929..21898978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)