U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Comtd1 catechol-O-methyltransferase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69156, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Comtd1provided by MGI
Official Full Name
catechol-O-methyltransferase domain containing 1provided by MGI
Primary source
MGI:MGI:1916406
See related
Ensembl:ENSMUSG00000021773 AllianceGenome:MGI:1916406
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT773; 1810030M08Rik
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Located in mitochondrion. Is expressed in alimentary system; liver; and nervous system. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 17.1), stomach adult (RPKM 16.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Comtd1 in Genome Data Viewer
Location:
14 A3; 14 11.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21895929..21898978, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21845861..21848910, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10820 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene predicted gene, 23502 Neighboring gene RIKEN cDNA A430057M04 gene Neighboring gene STARR-positive B cell enhancer mm9_chr14:22668101-22668402 Neighboring gene voltage-dependent anion channel 2 Neighboring gene STARR-seq mESC enhancer starr_36154 Neighboring gene STARR-seq mESC enhancer starr_36155 Neighboring gene RIKEN cDNA A330001L22 gene Neighboring gene zinc finger protein 503

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken. Bi H, et al. PLoS Genet, 2023 Apr. PMID 37068079, Free PMC Article
  2. Regulation of epithelial Na+ channels (ENaC) by methylation: a novel methyltransferase stimulates ENaC activity. Edinger RS, et al. J Biol Chem, 2006 Apr 7. PMID 16469734
  3. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.
    Title: A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
catechol O-methyltransferase domain-containing protein 1
Names
O-methyltransferase-containing protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026965.2 → NP_081241.1  catechol O-methyltransferase domain-containing protein 1

    See identical proteins and their annotated locations for NP_081241.1

    Status: PROVISIONAL

    Source sequence(s)
    AK054334
    Consensus CDS
    CCDS26868.1
    UniProtKB/Swiss-Prot
    Q8BIG7
    Related
    ENSMUSP00000119330.2, ENSMUST00000124549.9
    Conserved Domains (1) summary
    cl17173
    Location:60 → 261
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21895929..21898978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIG7.1 GenPept UniProtKB/Swiss-Prot:Q8BIG7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools