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COMTD1 catechol-O-methyltransferase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 118881, updated on 22-Sep-2022

Summary

Official Symbol
COMTD1provided by HGNC
Official Full Name
catechol-O-methyltransferase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26309
See related
Ensembl:ENSG00000165644 AllianceGenome:HGNC:26309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon (RPKM 11.0), stomach (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

See COMTD1 in Genome Data Viewer
Location:
10q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75233641..75235957, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (76107149..76109465, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76993399..76995715, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10124 Neighboring gene Sharpr-MPRA regulatory region 7934 Neighboring gene voltage dependent anion channel 2 Neighboring gene Sharpr-MPRA regulatory region 13796 Neighboring gene VISTA enhancer hs1437 Neighboring gene ribosomal protein L39 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
catechol O-methyltransferase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144589.4NP_653190.2  catechol O-methyltransferase domain-containing protein 1

    See identical proteins and their annotated locations for NP_653190.2

    Status: VALIDATED

    Source sequence(s)
    AK302283, AL390034, BC047774
    Consensus CDS
    CCDS7349.1
    UniProtKB/Swiss-Prot
    Q86VU5, Q8TE79
    Related
    ENSP00000361616.3, ENST00000372538.8
    Conserved Domains (1) summary
    cl17173
    Location:60261
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    75233641..75235957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    76107149..76109465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)