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Cnot8 CCR4-NOT transcription complex, subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 69125, updated on 5-Jan-2023

Summary

Official Symbol
Cnot8provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 8provided by MGI
Primary source
MGI:MGI:1916375
See related
Ensembl:ENSMUSG00000020515 AllianceGenome:MGI:1916375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500015I04Rik; 1810022F04Rik
Summary
Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Predicted to act upstream of or within gene silencing by RNA and regulation of translation. Predicted to be located in nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 34.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
Orthologs
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Genomic context

See Cnot8 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57983620..58009423)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58092794..58118597)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene predicted gene, 51897 Neighboring gene predicted gene 12248 Neighboring gene predicted gene 12247 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene mitochondrial ribosomal protein L22

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 8
Names
CCR4-associated factor 8
NP_001343406.1
NP_001350013.1
NP_001350014.1
NP_001350015.1
NP_081225.1
XP_006534165.1
XP_036012844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356477.2NP_001343406.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AK007581, AK075727, AK150757, BY419531
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532
    UniProtKB/TrEMBL
    A0A6P7RF53
    Related
    ENSMUSP00000104471.2, ENSMUST00000108843.8
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  2. NM_001363084.1NP_001350013.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AL672182, BB843287
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532
    UniProtKB/TrEMBL
    A0A6P7RF53
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  3. NM_001363085.1NP_001350014.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AL672182
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532
    UniProtKB/TrEMBL
    A0A6P7RF53
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  4. NM_001363086.1NP_001350015.1  CCR4-NOT transcription complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AL672182
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532
    UniProtKB/TrEMBL
    A0A6P7RF53
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  5. NM_026949.5NP_081225.1  CCR4-NOT transcription complex subunit 8

    See identical proteins and their annotated locations for NP_081225.1

    Status: VALIDATED

    Source sequence(s)
    AK075727, AK150757, BY419531, CD553562
    Consensus CDS
    CCDS24722.1
    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    UniProtKB/TrEMBL
    A0A6P7RF53
    Related
    ENSMUSP00000020822.6, ENSMUST00000020822.12
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    57983620..58009423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534102.2XP_006534165.1  CCR4-NOT transcription complex subunit 8 isoform X1

    See identical proteins and their annotated locations for XP_006534165.1

    UniProtKB/Swiss-Prot
    Q3U532, Q9D8X5
    UniProtKB/TrEMBL
    A0A6P7RF53
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  2. XM_036156951.1XP_036012844.1  CCR4-NOT transcription complex subunit 8 isoform X2