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CNOT8 CCR4-NOT transcription complex subunit 8 [ Homo sapiens (human) ]

Gene ID: 9337, updated on 6-Sep-2022

Summary

Official Symbol
CNOT8provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 8provided by HGNC
Primary source
HGNC:HGNC:9207
See related
Ensembl:ENSG00000155508 MIM:603731; AllianceGenome:HGNC:9207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAF1; POP2; CALIF; Caf1b; hCAF1
Summary
Enables poly(A)-specific ribonuclease activity. Involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues See more
Orthologs
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Genomic context

See CNOT8 in Genome Data Viewer
Location:
5q33.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (154858249..154876792)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (155392211..155410754)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154237809..154256352)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene Sharpr-MPRA regulatory region 2591 Neighboring gene uncharacterized LOC124901119 Neighboring gene gem nuclear organelle associated protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IC
Inferred by Curator
more info
PubMed 
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 8
Names
CAF1-like protein
CAF2
CALIFp
CCR4-associated factor 8
PGK promoter directed over production
NP_001288002.1
NP_001288003.1
NP_001288004.1
NP_001288006.1
NP_001288009.1
NP_001288011.1
NP_001288012.1
NP_001288015.1
NP_004770.4
XP_016865539.1
XP_016865540.1
XP_016865543.1
XP_016865544.1
XP_016865545.1
XP_047273836.1
XP_047273837.1
XP_047273838.1
XP_047273839.1
XP_047273840.1
XP_047273841.1
XP_047273842.1
XP_047273843.1
XP_047273844.1
XP_047273845.1
XP_047273846.1
XP_047273847.1
XP_047273848.1
XP_047273849.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301073.2NP_001288002.1  CCR4-NOT transcription complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_001288002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and encode the same isoform (1), compared to variant 1.
    Source sequence(s)
    AK025358, AL122045
    Consensus CDS
    CCDS4329.1
    UniProtKB/Swiss-Prot
    Q9H6Y1, Q9UFF9
    Related
    ENSP00000285896.6, ENST00000285896.11
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  2. NM_001301074.2NP_001288003.1  CCR4-NOT transcription complex subunit 8 isoform 2

    See identical proteins and their annotated locations for NP_001288003.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK303775, AK314317, AL122045
    Consensus CDS
    CCDS75361.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000430833.1, ENST00000519404.5
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  3. NM_001301075.2NP_001288004.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK297381, AK314317, AL122045
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  4. NM_001301077.2NP_001288006.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK309359, AL122045, DC387160
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000429882.1, ENST00000521583.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  5. NM_001301080.2NP_001288009.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate splice site and lacks two internal exons in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK315864, AL122045
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000428305.1, ENST00000520671.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  6. NM_001301082.1NP_001288011.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK316221, AL122045
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000431034.1, ENST00000521450.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  7. NM_001301083.1NP_001288012.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' UTR exon and also lacks two consecutive internal exons, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK316269, AL122045, AL520837
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000428565.1, ENST00000523698.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  8. NM_001301086.2NP_001288015.1  CCR4-NOT transcription complex subunit 8 isoform 4

    See identical proteins and their annotated locations for NP_001288015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate splice site and lacks two internal exons in the 5' region, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to variant 1.
    Source sequence(s)
    AK315864, AK316055, AL122045
    Consensus CDS
    CCDS78075.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    UniProtKB/TrEMBL
    B7Z9U0
    Related
    ENSP00000429576.1, ENST00000524105.5
    Conserved Domains (1) summary
    cl23804
    Location:199
    CAF1; CAF1 family ribonuclease
  9. NM_004779.6NP_004770.4  CCR4-NOT transcription complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_004770.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AK314317, AL122045
    Consensus CDS
    CCDS4329.1
    UniProtKB/Swiss-Prot
    Q9H6Y1, Q9UFF9
    Related
    ENSP00000384747.2, ENST00000403027.6
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    154858249..154876792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417891.1XP_047273847.1  CCR4-NOT transcription complex subunit 8 isoform X3

  2. XM_047417890.1XP_047273846.1  CCR4-NOT transcription complex subunit 8 isoform X3

  3. XM_047417892.1XP_047273848.1  CCR4-NOT transcription complex subunit 8 isoform X4

    UniProtKB/TrEMBL
    B7Z9U0
  4. XM_047417881.1XP_047273837.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6Y1
  5. XM_047417882.1XP_047273838.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6Y1
  6. XM_047417880.1XP_047273836.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6Y1
  7. XM_047417885.1XP_047273841.1  CCR4-NOT transcription complex subunit 8 isoform X2

  8. XM_017010051.2XP_016865540.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6Y1, Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  9. XM_017010055.3XP_016865544.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000429394.1, ENST00000518775.5
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  10. XM_047417884.1XP_047273840.1  CCR4-NOT transcription complex subunit 8 isoform X2

  11. XM_047417889.1XP_047273845.1  CCR4-NOT transcription complex subunit 8 isoform X3

  12. XM_017010050.2XP_016865539.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6Y1, Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  13. XM_017010054.3XP_016865543.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  14. XM_047417888.1XP_047273844.1  CCR4-NOT transcription complex subunit 8 isoform X3

  15. XM_047417883.1XP_047273839.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6Y1
  16. XM_047417893.1XP_047273849.1  CCR4-NOT transcription complex subunit 8 isoform X5

    UniProtKB/TrEMBL
    E5RHL9
    Related
    ENSP00000428576.1, ENST00000522644.5
  17. XM_017010056.2XP_016865545.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  18. XM_047417886.1XP_047273842.1  CCR4-NOT transcription complex subunit 8 isoform X2

  19. XM_047417887.1XP_047273843.1  CCR4-NOT transcription complex subunit 8 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    155392211..155410754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)