Format

Send to:

Choose Destination

CNOT8 CCR4-NOT transcription complex subunit 8 [ Homo sapiens (human) ]

Gene ID: 9337, updated on 21-Dec-2019

Summary

Official Symbol
CNOT8provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 8provided by HGNC
Primary source
HGNC:HGNC:9207
See related
Ensembl:ENSG00000155508 MIM:603731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAF1; POP2; CALIF; Caf1b; hCAF1
Expression
Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues See more
Orthologs

Genomic context

See CNOT8 in Genome Data Viewer
Location:
5q33.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (154857952..154876792)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154237755..154256352)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene uncharacterized LOC112267936 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene mitochondrial ribosomal protein L22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 8
Names
CAF1-like protein
CAF2
CALIFp
CCR4-associated factor 8
PGK promoter directed over production
NP_001288002.1
NP_001288003.1
NP_001288004.1
NP_001288006.1
NP_001288009.1
NP_001288011.1
NP_001288012.1
NP_001288015.1
NP_004770.4
XP_005268584.1
XP_011536008.1
XP_011536010.1
XP_016865537.1
XP_016865538.1
XP_016865539.1
XP_016865540.1
XP_016865541.1
XP_016865542.1
XP_016865543.1
XP_016865544.1
XP_016865545.1
XP_016865546.1
XP_016865547.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301073.2NP_001288002.1  CCR4-NOT transcription complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_001288002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and encode the same isoform (1), compared to variant 1.
    Source sequence(s)
    AK025358, AL122045
    Consensus CDS
    CCDS4329.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000285896.6, ENST00000285896.10
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  2. NM_001301074.2NP_001288003.1  CCR4-NOT transcription complex subunit 8 isoform 2

    See identical proteins and their annotated locations for NP_001288003.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK303775, AK314317, AL122045
    Consensus CDS
    CCDS75361.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000430833.1, ENST00000519404.5
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  3. NM_001301075.2NP_001288004.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK297381, AK314317, AL122045
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  4. NM_001301077.2NP_001288006.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK309359, AL122045, DC387160
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000429882.1, ENST00000521583.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  5. NM_001301080.2NP_001288009.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate splice site and lacks two internal exons in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK315864, AL122045
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000428305.1, ENST00000520671.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  6. NM_001301082.1NP_001288011.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK316221, AL122045
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000431034.1, ENST00000521450.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  7. NM_001301083.1NP_001288012.1  CCR4-NOT transcription complex subunit 8 isoform 3

    See identical proteins and their annotated locations for NP_001288012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' UTR exon and also lacks two consecutive internal exons, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
    Source sequence(s)
    AK316269, AL122045, AL520837
    Consensus CDS
    CCDS78074.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000428565.1, ENST00000523698.5
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  8. NM_001301086.2NP_001288015.1  CCR4-NOT transcription complex subunit 8 isoform 4

    See identical proteins and their annotated locations for NP_001288015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate splice site and lacks two internal exons in the 5' region, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to variant 1.
    Source sequence(s)
    AK315864, AK316055, AL122045
    Consensus CDS
    CCDS78075.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    UniProtKB/TrEMBL
    B7Z9U0
    Related
    ENSP00000429576.1, ENST00000524105.5
    Conserved Domains (1) summary
    cl23804
    Location:199
    CAF1; CAF1 family ribonuclease
  9. NM_004779.6NP_004770.4  CCR4-NOT transcription complex subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_004770.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AK314317, AL122045
    Consensus CDS
    CCDS4329.1
    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000384747.2, ENST00000403027.6
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    154857952..154876792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010051.1XP_016865540.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  2. XM_017010053.1XP_016865542.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  3. XM_005268527.2XP_005268584.1  CCR4-NOT transcription complex subunit 8 isoform X2

    See identical proteins and their annotated locations for XP_005268584.1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  4. XM_017010050.1XP_016865539.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  5. XM_017010052.1XP_016865541.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  6. XM_017010049.2XP_016865538.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  7. XM_011537708.2XP_011536010.1  CCR4-NOT transcription complex subunit 8 isoform X3

    See identical proteins and their annotated locations for XP_011536010.1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  8. XM_017010048.2XP_016865537.1  CCR4-NOT transcription complex subunit 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000430493.1, ENST00000517876.5
    Conserved Domains (1) summary
    cl23804
    Location:1263
    CAF1; CAF1 family ribonuclease
  9. XM_017010057.1XP_016865546.1  CCR4-NOT transcription complex subunit 8 isoform X3

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
  10. XM_017010055.2XP_016865544.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Related
    ENSP00000429394.1, ENST00000518775.5
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  11. XM_017010054.2XP_016865543.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  12. XM_017010058.2XP_016865547.1  CCR4-NOT transcription complex subunit 8 isoform X4

    UniProtKB/TrEMBL
    B7Z9U0
    Conserved Domains (1) summary
    cl23804
    Location:199
    CAF1; CAF1 family ribonuclease
  13. XM_017010056.1XP_016865545.1  CCR4-NOT transcription complex subunit 8 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1209
    CAF1; CAF1 family ribonuclease
  14. XM_011537706.1XP_011536008.1  CCR4-NOT transcription complex subunit 8 isoform X3

    See identical proteins and their annotated locations for XP_011536008.1

    UniProtKB/Swiss-Prot
    Q9UFF9
    Conserved Domains (1) summary
    cl23804
    Location:1157
    CAF1; CAF1 family ribonuclease
Support Center