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Trim15 tripartite motif-containing 15 [ Mus musculus (house mouse) ]

Gene ID: 69097, updated on 21-Apr-2024

Summary

Official Symbol
Trim15provided by MGI
Official Full Name
tripartite motif-containing 15provided by MGI
Primary source
MGI:MGI:1916347
See related
Ensembl:ENSMUSG00000050747 AllianceGenome:MGI:1916347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810012B10Rik
Summary
Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of intracellular transport of viral material; and regulation of gene expression. Predicted to be active in cytoplasm. Orthologous to human TRIM15 (tripartite motif containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 14.4), small intestine adult (RPKM 8.1) and 3 other tissues See more
Orthologs
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Genomic context

Location:
17 B1; 17 19.16 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37171582..37179066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36860690..36867367, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 10.6 Neighboring gene STARR-positive B cell enhancer ABC_E612 Neighboring gene tripartite motif-containing 26 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 10 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM15
Names
tripartite motif protein 15
NP_001019305.1
NP_001171343.1
XP_036016670.1
XP_036016671.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024134.2NP_001019305.1  E3 ubiquitin-protein ligase TRIM15 isoform 2

    See identical proteins and their annotated locations for NP_001019305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 3' CDS, as compared to variant 1, resulting in a reading frame shift. The resulting isoform (2) is slightly shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    CR956641
    Consensus CDS
    CCDS50102.1
    UniProtKB/TrEMBL
    Q8R096
    Related
    ENSMUSP00000025329.7, ENSMUST00000025329.13
    Conserved Domains (3) summary
    cd00021
    Location:76114
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:1553
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:193290
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. NM_001177872.1NP_001171343.1  E3 ubiquitin-protein ligase TRIM15 isoform 1

    See identical proteins and their annotated locations for NP_001171343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CR956641
    Consensus CDS
    CCDS57079.1
    UniProtKB/TrEMBL
    G3UY57
    Related
    ENSMUSP00000133953.2, ENSMUST00000174195.8
    Conserved Domains (3) summary
    cd00021
    Location:76114
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:1553
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:193290
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37171582..37179066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160777.1XP_036016670.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    Conserved Domains (4) summary
    COG1196
    Location:122269
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00162
    Location:1553
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:76114
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:1554
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_036160778.1XP_036016671.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

RNA

  1. XR_385361.5 RNA Sequence

  2. XR_876527.1 RNA Sequence