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TRIM15 tripartite motif containing 15 [ Homo sapiens (human) ]

Gene ID: 89870, updated on 21-Dec-2019

Summary

Official Symbol
TRIM15provided by HGNC
Official Full Name
tripartite motif containing 15provided by HGNC
Primary source
HGNC:HGNC:16284
See related
Ensembl:ENSG00000204610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF93; ZNFB7; ZNF178
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 12.6), small intestine (RPKM 9.2) and 6 other tissues See more
Orthologs

Genomic context

See TRIM15 in Genome Data Viewer
Location:
6p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30163546..30172693)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30130968..30140473)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 40 Neighboring gene tripartite motif containing 10 Neighboring gene tripartite motif containing 26 Neighboring gene poly(A) binding protein interacting protein 1 pseudogene 1 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Fluorescence microscope analysis demonstrates a reduction of HIV-1 Gag fluorescence at the plasma membrane in cells containing cytoplasmic TRIM15 bodies PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
tripartite motif-containing protein 15
Names
RING finger protein 93
zinc finger protein 178
zinc finger protein B7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033229.3NP_150232.2  tripartite motif-containing protein 15

    See identical proteins and their annotated locations for NP_150232.2

    Status: REVIEWED

    Source sequence(s)
    AI739162, AL669914, BC038585, BP270476, U34249
    Consensus CDS
    CCDS4677.1
    UniProtKB/Swiss-Prot
    Q9C019
    UniProtKB/TrEMBL
    Q5SRL0
    Related
    ENSP00000365884.4, ENST00000376694.9
    Conserved Domains (5) summary
    smart00336
    Location:80119
    BBOX; B-Box-type zinc finger
    pfam09088
    Location:252327
    MIF4G_like; MIF4G like
    cd15826
    Location:295464
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    cd16543
    Location:1661
    RING-HC_RNF135_like; RING finger, HC subclass, found in RING finger protein 135 (RNF135), tripartite motif-containing protein 15 (TRIM15) and similar proteins
    cl25732
    Location:121241
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30163546..30172693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514987.1XP_011513289.1  tripartite motif-containing protein 15 isoform X1

    Conserved Domains (2) summary
    pfam09088
    Location:147222
    MIF4G_like; MIF4G like
    cd15826
    Location:190359
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
  2. XM_011514988.2XP_011513290.1  tripartite motif-containing protein 15 isoform X2

    See identical proteins and their annotated locations for XP_011513290.1

    Conserved Domains (2) summary
    pfam09088
    Location:45120
    MIF4G_like; MIF4G like
    cd15826
    Location:88257
    SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1421626..1430773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1643344..1652491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1419447..1428594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1474248..1483395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    1507619..1516766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1418674..1427821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    1462477..1471624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_052812.1: Suppressed sequence

    Description
    NM_052812.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
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