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Fuom fucose mutarotase [ Mus musculus (house mouse) ]

Gene ID: 69064, updated on 8-May-2024

Summary

Official Symbol
Fuomprovided by MGI
Official Full Name
fucose mutarotaseprovided by MGI
Primary source
MGI:MGI:1916314
See related
Ensembl:ENSMUSG00000025466 AllianceGenome:MGI:1916314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fucu; Le51
Summary
Enables L-fucose mutarotase activity and fucose binding activity. Involved in fucose metabolic process. Acts upstream of or within female mating behavior; fucosylation; and negative regulation of neuron differentiation. Orthologous to human FUOM (fucose mutarotase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 5.8), kidney adult (RPKM 4.8) and 27 other tissues See more
Orthologs
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Genomic context

See Fuom in Genome Data Viewer
Location:
7 F4; 7 85.11 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139677724..139684745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140097811..140104832, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20446 Neighboring gene calcyon neuron-specific vesicular protein Neighboring gene STARR-seq mESC enhancer starr_20447 Neighboring gene proline-rich acidic protein 1 Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene polyamine oxidase (exo-N4-amino) Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • 1810014F10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-fucose mutarotase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fucose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fucose binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables monosaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IBA
Inferred from Biological aspect of Ancestor
more info
 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within female mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fucosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
fucose mutarotase
Names
protein fucU homolog
NP_001273146.1
NP_001273147.2
NP_081204.2
XP_011248157.1
XP_030098825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286217.2NP_001273146.1  fucose mutarotase isoform 2

    See identical proteins and their annotated locations for NP_001273146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC109205
    UniProtKB/TrEMBL
    F6SJM7
    Related
    ENSMUSP00000115799.2, ENSMUST00000142105.8
    Conserved Domains (1) summary
    cl00809
    Location:4133
    RbsD_FucU; RbsD / FucU transport protein family
  2. NM_001286218.2NP_001273147.2  fucose mutarotase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift and initiation from an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC109205
    Conserved Domains (1) summary
    pfam05025
    Location:4699
    RbsD_FucU; RbsD / FucU transport protein family
  3. NM_026928.4NP_081204.2  fucose mutarotase isoform 1

    See identical proteins and their annotated locations for NP_081204.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC109205
    Consensus CDS
    CCDS40173.1
    UniProtKB/Swiss-Prot
    Q3TQB6, Q76K68, Q8C566, Q8C8P5, Q8R2K1
    UniProtKB/TrEMBL
    D3YWS7
    Related
    ENSMUSP00000026539.8, ENSMUST00000026539.14
    Conserved Domains (1) summary
    cl00809
    Location:4146
    RbsD_FucU; RbsD / FucU transport protein family

RNA

  1. NR_104415.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109205, AK044731

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139677724..139684745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242965.1XP_030098825.1  fucose mutarotase isoform X1

    UniProtKB/TrEMBL
    F6SJM7
    Conserved Domains (1) summary
    pfam05025
    Location:5149
    RbsD_FucU; RbsD / FucU transport protein family
  2. XM_011249855.3XP_011248157.1  fucose mutarotase isoform X2

    UniProtKB/TrEMBL
    D3YWS7
    Conserved Domains (1) summary
    pfam05025
    Location:5159
    RbsD_FucU; RbsD / FucU transport protein family

RNA

  1. XR_004934184.1 RNA Sequence

  2. XR_003946558.1 RNA Sequence

  3. XR_004934183.1 RNA Sequence