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Fuom fucose mutarotase [ Mus musculus (house mouse) ]

Gene ID: 69064, updated on 2-Nov-2024

Summary

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Official Symbol
Fuomprovided by MGI
Official Full Name
fucose mutarotaseprovided by MGI
Primary source
MGI:MGI:1916314
See related
Ensembl:ENSMUSG00000025466 AllianceGenome:MGI:1916314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fucu; Le51
Summary
Enables L-fucose mutarotase activity and fucose binding activity. Involved in GDP-L-fucose salvage and fucose metabolic process. Acts upstream of or within female mating behavior; fucosylation; and negative regulation of neuron differentiation. Is active in cytosol. Orthologous to human FUOM (fucose mutarotase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 5.8), kidney adult (RPKM 4.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fuom in Genome Data Viewer
Location:
7 F4; 7 85.11 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139677724..139684745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140097811..140104832, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20446 Neighboring gene calcyon neuron-specific vesicular protein Neighboring gene STARR-seq mESC enhancer starr_20447 Neighboring gene proline-rich acidic protein 1 Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene polyamine oxidase (exo-N4-amino) Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel system for expressing recombinant proteins over a wide temperature range from 4 to 35 degrees C. Nakashima N, et al. Biotechnol Bioeng, 2004 Apr 20. PMID 15052633
  2. Characterization and role of fucose mutarotase in mammalian cells. Park D, et al. Glycobiology, 2007 Sep. PMID 17602138
  3. Male-like sexual behavior of female mouse lacking fucose mutarotase. Park D, et al. BMC Genet, 2010 Jul 7. PMID 20609214, Free PMC Article
  4. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. Lee KH, et al. J Mol Biol, 2009 Aug 7. PMID 19524593
  5. Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture. Kim MS, et al. J Biol Chem, 2003 Jul 25. PMID 12738765

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • 1810014F10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-fucose mutarotase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fucose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucose binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IBA
Inferred from Biological aspect of Ancestor
more info
  
enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GDP-L-fucose salvage IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within female mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fucosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fucose mutarotase
Names
protein fucU homolog
NP_001273146.1
NP_001273147.2
NP_081204.2
XP_011248157.1
XP_030098825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286217.2 → NP_001273146.1  fucose mutarotase isoform 2

    See identical proteins and their annotated locations for NP_001273146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC109205
    UniProtKB/TrEMBL
    F6SJM7
    Related
    ENSMUSP00000115799.2, ENSMUST00000142105.8
    Conserved Domains (1) summary
    cl00809
    Location:4 → 133
    RbsD_FucU; RbsD / FucU transport protein family

  2. NM_001286218.2 → NP_001273147.2  fucose mutarotase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift and initiation from an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC109205
    Conserved Domains (1) summary
    pfam05025
    Location:46 → 99
    RbsD_FucU; RbsD / FucU transport protein family

  3. NM_026928.4 → NP_081204.2  fucose mutarotase isoform 1

    See identical proteins and their annotated locations for NP_081204.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC109205
    Consensus CDS
    CCDS40173.1
    UniProtKB/Swiss-Prot
    Q3TQB6, Q76K68, Q8C566, Q8C8P5, Q8R2K1
    UniProtKB/TrEMBL
    D3YWS7
    Related
    ENSMUSP00000026539.8, ENSMUST00000026539.14
    Conserved Domains (1) summary
    cl00809
    Location:4 → 146
    RbsD_FucU; RbsD / FucU transport protein family

RNA

  1. NR_104415.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109205, AK044731

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139677724..139684745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242965.1 → XP_030098825.1  fucose mutarotase isoform X1

    UniProtKB/TrEMBL
    F6SJM7
    Conserved Domains (1) summary
    pfam05025
    Location:5 → 149
    RbsD_FucU; RbsD / FucU transport protein family

  2. XM_011249855.3 → XP_011248157.1  fucose mutarotase isoform X2

    UniProtKB/TrEMBL
    D3YWS7
    Conserved Domains (1) summary
    pfam05025
    Location:5 → 159
    RbsD_FucU; RbsD / FucU transport protein family

RNA

  1. XR_004934184.1 RNA Sequence

  2. XR_003946558.1 RNA Sequence

  3. XR_004934183.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2K1.1 GenPept UniProtKB/Swiss-Prot:Q8R2K1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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