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FUOM fucose mutarotase [ Homo sapiens (human) ]

Gene ID: 282969, updated on 24-Nov-2020

Summary

Official Symbol
FUOMprovided by HGNC
Official Full Name
fucose mutarotaseprovided by HGNC
Primary source
HGNC:HGNC:24733
See related
Ensembl:ENSG00000148803 MIM:617725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FUCU; FucM; C10orf125
Expression
Broad expression in liver (RPKM 9.1), duodenum (RPKM 5.8) and 21 other tissues See more
Orthologs

Genomic context

See FUOM in Genome Data Viewer
Location:
10q26.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133352773..133358031, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135168658..135171529, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BANF1 pseudogene 2 Neighboring gene proline rich acidic protein 1 Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944 Neighboring gene polyamine oxidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26016, MGC149258

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-fucose mutarotase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fucose binding ISS
Inferred from Sequence or Structural Similarity
more info
 
racemase and epimerase activity, acting on carbohydrates and derivatives IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
racemase and epimerase activity, acting on carbohydrates and derivatives ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
female mating behavior IEA
Inferred from Electronic Annotation
more info
 
fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
fucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fucose mutarotase
Names
protein fucU homolog
NP_001091953.1
NP_001288756.1
NP_001288757.1
NP_940874.2
XP_011537972.1
XP_011537973.1
XP_011537974.1
XP_011537975.1
XP_011537976.1
XP_011537977.1
XP_016871583.1
XP_024303714.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098483.3NP_001091953.1  fucose mutarotase isoform 1

    See identical proteins and their annotated locations for NP_001091953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI333356, HY163253
    Consensus CDS
    CCDS44499.1
    UniProtKB/Swiss-Prot
    A2VDF0
    Related
    ENSP00000278025.5, ENST00000278025.9
    Conserved Domains (1) summary
    cl00809
    Location:4147
    RbsD_FucU; RbsD / FucU transport protein family
  2. NM_001301827.2NP_001288756.1  fucose mutarotase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AI333356, AK129527, BM009909
    UniProtKB/Swiss-Prot
    A2VDF0
    Related
    ENSP00000413379.2, ENST00000447176.5
    Conserved Domains (1) summary
    cl00809
    Location:4124
    RbsD_FucU; RbsD / FucU transport protein family
  3. NM_001301828.2NP_001288757.1  fucose mutarotase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AI333356, AK129527, BU849497
    Consensus CDS
    CCDS76364.1
    UniProtKB/Swiss-Prot
    A2VDF0
    UniProtKB/TrEMBL
    X6R6T9
    Related
    ENSP00000357539.1, ENST00000368551.1
    Conserved Domains (1) summary
    cl00809
    Location:3102
    RbsD_FucU; RbsD / FucU transport protein family
  4. NM_198472.3NP_940874.2  fucose mutarotase isoform 2

    See identical proteins and their annotated locations for NP_940874.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK129527, BC129819, CN368132
    Consensus CDS
    CCDS7680.1
    UniProtKB/Swiss-Prot
    A2VDF0
    Related
    ENSP00000357540.5, ENST00000368552.7
    Conserved Domains (1) summary
    cl00809
    Location:4133
    RbsD_FucU; RbsD / FucU transport protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133352773..133358031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539673.2XP_011537975.1  fucose mutarotase isoform X4

    Conserved Domains (1) summary
    cl00809
    Location:4144
    RbsD_FucU; RbsD / FucU transport protein family
  2. XM_011539675.2XP_011537977.1  fucose mutarotase isoform X6

    Conserved Domains (1) summary
    cl00809
    Location:4133
    RbsD_FucU; RbsD / FucU transport protein family
  3. XM_011539671.2XP_011537973.1  fucose mutarotase isoform X2

    Conserved Domains (1) summary
    cl00809
    Location:4158
    RbsD_FucU; RbsD / FucU transport protein family
  4. XM_011539672.2XP_011537974.1  fucose mutarotase isoform X3

    Conserved Domains (1) summary
    cl00809
    Location:4158
    RbsD_FucU; RbsD / FucU transport protein family
  5. XM_011539670.2XP_011537972.1  fucose mutarotase isoform X1

    Conserved Domains (1) summary
    cl00809
    Location:4169
    RbsD_FucU; RbsD / FucU transport protein family
  6. XM_024447946.1XP_024303714.1  fucose mutarotase isoform X8

    Conserved Domains (1) summary
    cl00809
    Location:3113
    RbsD_FucU; RbsD / FucU transport protein family
  7. XM_017016094.1XP_016871583.1  fucose mutarotase isoform X7

  8. XM_011539674.2XP_011537976.1  fucose mutarotase isoform X5

    Conserved Domains (1) summary
    cl00809
    Location:4144
    RbsD_FucU; RbsD / FucU transport protein family
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