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Cdan1 congenital dyserythropoietic anemia, type I (human) [ Mus musculus (house mouse) ]

Gene ID: 68968, updated on 26-Sep-2022

Summary

Official Symbol
Cdan1provided by MGI
Official Full Name
congenital dyserythropoietic anemia, type I (human)provided by MGI
Primary source
MGI:MGI:1916218
See related
Ensembl:ENSMUSG00000027284 AllianceGenome:MGI:1916218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDA1; CDAI; CDA-I; 1500015A01Rik
Summary
Predicted to be involved in chromatin assembly and negative regulation of DNA replication. Predicted to act upstream of or within protein localization. Located in endomembrane system and nucleus. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia and congenital dyserythropoietic anemia type Ia. Orthologous to human CDAN1 (codanin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 17.2), testis adult (RPKM 7.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cdan1 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120546635..120561998, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120716154..120731517, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene synaptosomal-associated protein 23 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene START domain containing 9 Neighboring gene tau tubulin kinase 2 Neighboring gene expressed sequence AV039307 Neighboring gene ubiquitin protein ligase E3 component n-recognin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Ttbk2

Homology

Clone Names

  • MGC144128

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
 
involved_in import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear envelope organization TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
codanin-1
Names
congenital dyserythropoietic anemia type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026891.2NP_081167.2  codanin-1

    See identical proteins and their annotated locations for NP_081167.2

    Status: VALIDATED

    Source sequence(s)
    AK034144, AK134300, AL935168, BC117555
    Consensus CDS
    CCDS38212.1
    UniProtKB/Swiss-Prot
    Q3U032, Q8CC12
    Related
    ENSMUSP00000106329.2, ENSMUST00000110701.8
    Conserved Domains (2) summary
    pfam15229
    Location:130306
    POM121; POM121 family
    pfam15296
    Location:789904
    Codanin-1_C; Codanin-1 C-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120546635..120561998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)