Format

Send to:

Choose Destination

Ttbk2 tau tubulin kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 140810, updated on 12-Aug-2018

Summary

Official Symbol
Ttbk2provided by MGI
Official Full Name
tau tubulin kinase 2provided by MGI
Primary source
MGI:MGI:2155779
See related
Ensembl:ENSMUSG00000090100 Vega:OTTMUSG00000015707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TTK; Ttbk; Ttbk1; AI326283; mKIAA0847; 2610507N02Rik; B930008N24Rik
Annotation information
Note: This record was renamed from Ttbk1 to Ttbk2 to conform to the annotation of human. [11 Apr 2007]
Expression
Broad expression in testis adult (RPKM 17.3), cerebellum adult (RPKM 7.9) and 15 other tissues See more
Orthologs

Genomic context

See Ttbk2 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (120732816..120850584, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120558552..120676320, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene START domain containing 9 Neighboring gene predicted gene, 46789 Neighboring gene congenital dyserythropoietic anemia, type I (human) Neighboring gene expressed sequence AV039307 Neighboring gene ubiquitin protein ligase E3 component n-recognin 1 Neighboring gene transmembrane protein 62 Neighboring gene U3B small nuclear RNA pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Potential readthrough

Included gene: Cdan1

Homology

Clone Names

  • KIAA0847

Gene Ontology Provided by MGI

Function Evidence Code Pubs
kinesin binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cerebellar granular layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellar granule cell precursor tangential migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly ISO
Inferred from Sequence Orthology
more info
 
embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
 
neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centriole ISO
Inferred from Sequence Orthology
more info
 
ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary transition zone IDA
Inferred from Direct Assay
more info
PubMed 
ciliary transition zone ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tau-tubulin kinase 2
Names
protein bartleby
NP_001020027.1
NP_001020028.1
NP_542966.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024856.2NP_001020027.1  tau-tubulin kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001020027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' end exon compared to transcript variant 1. It encodes an isoform (2) that is shorter and with a distinct N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK046978, AK148269, AK161858, AL935168
    Consensus CDS
    CCDS16627.1
    UniProtKB/Swiss-Prot
    Q3UVR3
    Related
    ENSMUSP00000083001.4, ENSMUST00000085840.10
    Conserved Domains (2) summary
    cd14129
    Location:20281
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2
    pfam00069
    Location:21260
    Pkinase; Protein kinase domain
  2. NM_001024857.2NP_001020028.1  tau-tubulin kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001020028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is missing a non-coding exon compared to transcript variant 2. Both variants encode the same isoform (2).
    Source sequence(s)
    AK046978, AK137024, AK148269, AK161858, AL935168
    Consensus CDS
    CCDS16627.1
    UniProtKB/Swiss-Prot
    Q3UVR3
    Related
    ENSMUSP00000055032.7, OTTMUSP00000016715, ENSMUST00000057135.13, OTTMUST00000037321
    Conserved Domains (2) summary
    cd14129
    Location:20281
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2
    pfam00069
    Location:21260
    Pkinase; Protein kinase domain
  3. NM_080788.3NP_542966.2  tau-tubulin kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_542966.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK046978, AK161858, AL935168, BY106085
    Consensus CDS
    CCDS16626.1
    UniProtKB/Swiss-Prot
    Q3UVR3
    UniProtKB/TrEMBL
    A2AW15
    Related
    ENSMUSP00000028740.4, OTTMUSP00000016716, ENSMUST00000028740.10, OTTMUST00000037322
    Conserved Domains (2) summary
    cd14129
    Location:89350
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2
    pfam00069
    Location:90329
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    120732816..120850584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center