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Nrip2 nuclear receptor interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689619, updated on 17-Aug-2024

Summary

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Symbol
Nrip2provided by RGD
Full Name
nuclear receptor interacting protein 2provided by RGD
Primary source
RGD:1589959
See related
EnsemblRapid:ENSRNOG00000063347 AllianceGenome:RGD:1589959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human NRIP2 (nuclear receptor interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 34.8), Lung (RPKM 25.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163359592..163370144)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161673964..161684055)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (161719434..161729673)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene forkhead box M1 Neighboring gene testis expressed 52 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene uncharacterized LOC120102402 Neighboring gene FKBP prolyl isomerase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Greiner EF, et al. Proc Natl Acad Sci U S A, 2000 Jun 20. PMID 10860982, Free PMC Article
  2. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Fouillade C, et al. Arterioscler Thromb Vasc Biol, 2013 Jan. PMID 23117660, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor interacting protein 2; nuclear receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431912.1 → NP_001418841.1  nuclear receptor interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  2. NM_001431913.1 → NP_001418842.1  nuclear receptor interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  3. NM_001431914.1 → NP_001418843.1  nuclear receptor interacting protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    163359592..163370144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593047.3 → XP_017448536.1  nuclear receptor-interacting protein 2 isoform X3

  2. XM_006237431.5 → XP_006237493.1  nuclear receptor-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006237493.1

    Conserved Domains (1) summary
    cl11403
    Location:110 → 199
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

  3. XM_063286865.1 → XP_063142935.1  nuclear receptor-interacting protein 2 isoform X4

  4. XM_001071392.8 → XP_001071392.2  nuclear receptor-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6APM8
    Related
    ENSRNOP00000094217.1, ENSRNOT00000105666.2
    Conserved Domains (1) summary
    cl11403
    Location:110 → 206
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein Strain
Heading Accession and Version

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