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Aspscr1 ASPSCR1 tether for SLC2A4, UBX domain containing [ Mus musculus (house mouse) ]

Gene ID: 68938, updated on 21-May-2024

Summary

Official Symbol
Aspscr1provided by MGI
Official Full Name
ASPSCR1 tether for SLC2A4, UBX domain containingprovided by MGI
Primary source
MGI:MGI:1916188
See related
Ensembl:ENSMUSG00000025142 AllianceGenome:MGI:1916188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TUG; ASPC; ASPL; ASPS; RCC17; ASPCR1; 1190006K01Rik
Summary
Acts upstream of or within glucose homeostasis; intracellular protein transport; and regulation of glucose import. Located in several cellular components, including cytoplasmic side of plasma membrane; perinuclear region of cytoplasm; and vesicle membrane. Is extrinsic component of membrane. Human ortholog(s) of this gene implicated in alveolar soft part sarcoma. Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2A4, UBX domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 52.7), duodenum adult (RPKM 26.9) and 28 other tissues See more
Orthologs
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Genomic context

See Aspscr1 in Genome Data Viewer
Location:
11 E2; 11 84.41 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120563878..120600273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120672973..120709447)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene notum palmitoleoyl-protein carboxylesterase Neighboring gene STARR-seq mESC enhancer starr_31365 Neighboring gene STARR-positive B cell enhancer ABC_E472 Neighboring gene centromere protein X Neighboring gene STARR-positive B cell enhancer ABC_E10737 Neighboring gene leucine rich repeat containing 45

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tether containing UBX domain for GLUT4
Names
alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog
alveolar soft part sarcoma chromosome region, candidate 1
tether, containing a UBX domain, for GLUT4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164224.1NP_001157696.1  tether containing UBX domain for GLUT4 isoform 3

    See identical proteins and their annotated locations for NP_001157696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK146061, AY349132
    Consensus CDS
    CCDS49008.1
    UniProtKB/Swiss-Prot
    Q8VBT9
    Related
    ENSMUSP00000101766.3, ENSMUST00000106160.9
    Conserved Domains (2) summary
    cd16118
    Location:310361
    UBX2_UBXN9; Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
    cd17075
    Location:1394
    UBX1_UBXN9; Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
  2. NM_001363055.2NP_001349984.1  tether containing UBX domain for GLUT4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Conserved Domains (1) summary
    pfam11470
    Location:1578
    TUG-UBL1; TUG ubiquitin-like domain
  3. NM_001363056.1NP_001349985.1  tether containing UBX domain for GLUT4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663030, AY349133
    Conserved Domains (2) summary
    pfam11470
    Location:463
    TUG-UBL1; TUG ubiquitin-like domain
    cl00155
    Location:370441
    UBQ; Ubiquitin-like proteins
  4. NM_001425434.1NP_001412363.1  tether containing UBX domain for GLUT4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663030
  5. NM_001425435.1NP_001412364.1  tether containing UBX domain for GLUT4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL663030
  6. NM_001425436.1NP_001412365.1  tether containing UBX domain for GLUT4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL663030
  7. NM_001425437.1NP_001412366.1  tether containing UBX domain for GLUT4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL663030
  8. NM_001425438.1NP_001412367.1  tether containing UBX domain for GLUT4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Related
    ENSMUSP00000101764.3, ENSMUST00000106158.9
  9. NM_001425439.1NP_001412368.1  tether containing UBX domain for GLUT4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL663030
  10. NM_026877.3NP_081153.1  tether containing UBX domain for GLUT4 isoform 1

    See identical proteins and their annotated locations for NP_081153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as the long isoform.
    Source sequence(s)
    AL663030
    Consensus CDS
    CCDS25751.1
    UniProtKB/Swiss-Prot
    A2ABZ7, A2AC06, Q3UKD1, Q6V7K5, Q8VBT9, Q9CT64
    Related
    ENSMUSP00000026135.9, ENSMUST00000026135.15
    Conserved Domains (2) summary
    pfam11470
    Location:1578
    TUG-UBL1; TUG ubiquitin-like domain
    cl00155
    Location:385456
    UBQ; Ubiquitin-like proteins
  11. NM_198223.2NP_937866.1  tether containing UBX domain for GLUT4 isoform 2

    See identical proteins and their annotated locations for NP_937866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2), also known as the short isoform, has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK146061, AY349132
    Consensus CDS
    CCDS25752.1
    UniProtKB/Swiss-Prot
    Q8VBT9
    Related
    ENSMUSP00000101765.4, ENSMUST00000106159.10
    Conserved Domains (2) summary
    cd16118
    Location:310382
    UBX2_UBXN9; Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
    cd17075
    Location:1394
    UBX1_UBXN9; Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins

RNA

  1. NR_189301.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663030
  2. NR_189302.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663030
  3. NR_189303.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663030

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120563878..120600273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156943.1XP_036012836.1  tether containing UBX domain for GLUT4 isoform X2

    Conserved Domains (2) summary
    cd16118
    Location:310382
    UBX2_UBXN9; Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
    cd17075
    Location:1394
    UBX1_UBXN9; Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
  2. XM_006534087.4XP_006534150.1  tether containing UBX domain for GLUT4 isoform X2

    See identical proteins and their annotated locations for XP_006534150.1

    UniProtKB/Swiss-Prot
    Q8VBT9
    Conserved Domains (2) summary
    cd16118
    Location:310382
    UBX2_UBXN9; Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
    cd17075
    Location:1394
    UBX1_UBXN9; Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins