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Disp1 dispatched RND transporter family member 1 [ Mus musculus (house mouse) ]

Gene ID: 68897, updated on 12-May-2024

Summary

Official Symbol
Disp1provided by MGI
Official Full Name
dispatched RND transporter family member 1provided by MGI
Primary source
MGI:MGI:1916147
See related
Ensembl:ENSMUSG00000030768 AllianceGenome:MGI:1916147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DispA; 1190008H24Rik
Summary
Enables peptide transmembrane transporter activity. Acts upstream of or within several processes, including determination of left/right symmetry; patched ligand maturation; and smoothened signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; foot bone; notochord; and palatal shelf. Orthologous to human DISP1 (dispatched RND transporter family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.4), ovary adult (RPKM 8.6) and 27 other tissues See more
Orthologs
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Genomic context

See Disp1 in Genome Data Viewer
Location:
1 H5; 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182867828..183010257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183086264..183221537, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene toll-like receptor 5 Neighboring gene predicted gene, 33747 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene axin interactor, dorsalization associated

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular carrier activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein dispatched homolog 1
Names
dispatched A
dispatched homolog 1
mdispa
twelve-pass transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278218.1NP_001265147.1  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_001265147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, BB732349, BC043102
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Related
    ENSMUSP00000141747.2, ENSMUST00000195372.2
    Conserved Domains (1) summary
    cl25655
    Location:4341114
    Patched; Patched family
  2. NM_001278219.1NP_001265148.1  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_001265148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, AK138276, BB732349, BC043102
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Conserved Domains (1) summary
    cl25655
    Location:4341114
    Patched; Patched family
  3. NM_001278220.1NP_001265149.1  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_001265149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, AY144589, BB732349, BC043102, BY792654
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Related
    ENSMUSP00000126742.2, ENSMUST00000171366.7
    Conserved Domains (1) summary
    cl25655
    Location:4341114
    Patched; Patched family
  4. NM_026866.3NP_081142.3  protein dispatched homolog 1

    See identical proteins and their annotated locations for NP_081142.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC122792, AK138276, BB732349, BC043102
    Consensus CDS
    CCDS56661.1
    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Related
    ENSMUSP00000003035.6, ENSMUST00000003035.12
    Conserved Domains (1) summary
    cl25655
    Location:4341114
    Patched; Patched family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    182867828..183010257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153394.1XP_036009287.1  protein dispatched homolog 1 isoform X3

    UniProtKB/Swiss-Prot
    Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
    Conserved Domains (1) summary
    cl25655
    Location:4341114
    Patched; Patched family
  2. XM_006535596.5XP_006535659.1  protein dispatched homolog 1 isoform X2

    Conserved Domains (1) summary
    cl25655
    Location:4681148
    Patched; Patched family
  3. XM_036153395.1XP_036009288.1  protein dispatched homolog 1 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:241921
    Patched; Patched family
  4. XM_036153391.1XP_036009284.1  protein dispatched homolog 1 isoform X1

    Conserved Domains (1) summary
    cl25655
    Location:4701150
    Patched; Patched family