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DISP1 dispatched RND transporter family member 1 [ Homo sapiens (human) ]

Gene ID: 84976, updated on 6-May-2020

Summary

Official Symbol
DISP1provided by HGNC
Official Full Name
dispatched RND transporter family member 1provided by HGNC
Primary source
HGNC:HGNC:19711
See related
Ensembl:ENSG00000154309 Ensembl:ENSG00000228106 MIM:607502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DISPA
Summary
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 5.0), testis (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See DISP1 in Genome Data Viewer
Location:
1q41
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (222814514..223005995)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222988342..223179337)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC105372984 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene family with sequence similarity 177 member B Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 2 Neighboring gene 1q41-q42 HERV-mediated distal recombination region Neighboring gene uncharacterized LOC102724046

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43740, MGC13130, MGC16796, MGC104180, DKFZp434I0428

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptide transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
diaphragm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
embryonic pattern specification IEA
Inferred from Electronic Annotation
more info
 
patched ligand maturation IEA
Inferred from Electronic Annotation
more info
 
peptide transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homotrimerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein dispatched homolog 1
Names
dispatched A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009243.2 RefSeqGene

    Range
    4951..195907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350630.2NP_001337559.1  protein dispatched homolog 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093152, AL392172, BC007734, BC011542, DA062334, DA756409, HY128909
    Conserved Domains (1) summary
    cl25655
    Location:192850
    Patched; Patched family
  2. NM_001369594.1NP_001356523.1  protein dispatched homolog 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC093152
    Related
    ENSP00000284476.6, ENST00000284476.7
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  3. NM_001377228.1NP_001364157.1  protein dispatched homolog 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC093152, AL392172
  4. NM_001377229.1NP_001364158.1  protein dispatched homolog 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC093152, AL392172
  5. NM_032890.5NP_116279.2  protein dispatched homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_116279.2

    Status: REVIEWED

    Source sequence(s)
    AC093152, AL392172, BC007734, BC011542, DA062334, DA756409
    Consensus CDS
    CCDS1536.1
    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family

RNA

  1. NR_165109.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000442171.5
  2. NR_165110.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  3. NR_165111.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  4. NR_165112.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000450784.5
  5. NR_165113.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  6. NR_165114.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  7. NR_165115.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  8. NR_165116.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  9. NR_165117.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000435378.5
  10. NR_165118.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000441676.5
  11. NR_165119.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  12. NR_165120.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  13. NR_165121.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000444858.5
  14. NR_165122.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  15. NR_165123.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  16. NR_165124.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  17. NR_165125.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000654502.1
  18. NR_165126.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  19. NR_165127.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  20. NR_165128.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  21. NR_165129.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  22. NR_165130.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  23. NR_165131.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  24. NR_165132.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  25. NR_165133.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  26. NR_165134.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  27. NR_165135.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  28. NR_165136.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  29. NR_165137.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  30. NR_165138.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  31. NR_165139.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  32. NR_165140.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  33. NR_165141.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  34. NR_165142.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  35. NR_165143.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  36. NR_165144.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000457636.5
  37. NR_165145.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  38. NR_165146.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  39. NR_165147.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  40. NR_165148.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  41. NR_165149.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  42. NR_165150.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  43. NR_165151.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  44. NR_165152.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  45. NR_165153.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  46. NR_165154.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  47. NR_165155.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000661663.1
  48. NR_165156.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
  49. NR_165157.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL392172
    Related
    ENST00000663328.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    222814514..223005995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510075.2XP_011508377.1  protein dispatched homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011508377.1

    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  2. XM_011510073.2XP_011508375.1  protein dispatched homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011508375.1

    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  3. XM_017002611.1XP_016858100.1  protein dispatched homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  4. XM_011510072.2XP_011508374.1  protein dispatched homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011508374.1

    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  5. XM_011510074.2XP_011508376.1  protein dispatched homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011508376.1

    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  6. XM_006711592.2XP_006711655.1  protein dispatched homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006711655.1

    UniProtKB/Swiss-Prot
    Q96F81
    Conserved Domains (1) summary
    cl25655
    Location:4351131
    Patched; Patched family
  7. XM_017002612.1XP_016858101.1  protein dispatched homolog 1 isoform X2

    Conserved Domains (2) summary
    pfam02460
    Location:262899
    Patched; Patched family
    cl21543
    Location:313477
    MMPL; MMPL family
  8. XM_006711594.3XP_006711657.1  protein dispatched homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006711657.1

    Conserved Domains (2) summary
    pfam02460
    Location:262899
    Patched; Patched family
    cl21543
    Location:313477
    MMPL; MMPL family
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