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TALDO1 transaldolase 1 [ Homo sapiens (human) ]

Gene ID: 6888, updated on 20-Dec-2019

Summary

Official Symbol
TALDO1provided by HGNC
Official Full Name
transaldolase 1provided by HGNC
Primary source
HGNC:HGNC:11559
See related
Ensembl:ENSG00000177156 MIM:602063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAL; TALH; TAL-H; TALDOR
Summary
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 165.6), esophagus (RPKM 127.9) and 25 other tissues See more
Orthologs

Genomic context

See TALDO1 in Genome Data Viewer
Location:
11p15.5
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (747464..765012)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (747417..765024)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DEAF1 transcription factor Neighboring gene EPS8 like 2 Neighboring gene uncharacterized LOC105376509 Neighboring gene glutamine amidotransferase like class 1 domain containing 1 Neighboring gene uncharacterized LOC171391

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
monosaccharide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glyceraldehyde-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xylulose biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
transaldolase
Names
dihydroxyacetone transferase
glycerone transferase
testicular secretory protein Li 56
NP_006746.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008160.1 RefSeqGene

    Range
    5033..22581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006755.2NP_006746.1  transaldolase

    See identical proteins and their annotated locations for NP_006746.1

    Status: REVIEWED

    Source sequence(s)
    L19437
    Consensus CDS
    CCDS7712.1
    UniProtKB/Swiss-Prot
    P37837
    UniProtKB/TrEMBL
    A0A140VK56
    Related
    ENSP00000321259.3, ENST00000319006.8
    Conserved Domains (1) summary
    PRK05269
    Location:11329
    PRK05269; transaldolase B; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    747464..765012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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