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Taldo1 transaldolase 1 [ Mus musculus (house mouse) ]

Gene ID: 21351, updated on 5-Feb-2023

Summary

Official Symbol
Taldo1provided by MGI
Official Full Name
transaldolase 1provided by MGI
Primary source
MGI:MGI:1274789
See related
Ensembl:ENSMUSG00000025503 AllianceGenome:MGI:1274789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in large intestine adult (RPKM 211.6), subcutaneous fat pad adult (RPKM 187.0) and 27 other tissues See more
Orthologs
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Genomic context

See Taldo1 in Genome Data Viewer
Location:
7; 7 F5
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140972073..140982889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141392160..141402976)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene EPS8-like 2 Neighboring gene RIKEN cDNA B230206H07 gene Neighboring gene predicted gene, 25725 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene glutamine amidotransferase like class 1 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transaldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transaldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transaldolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transaldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glyceraldehyde-3-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011528.4NP_035658.1  transaldolase

    See identical proteins and their annotated locations for NP_035658.1

    Status: REVIEWED

    Source sequence(s)
    AC163434
    Consensus CDS
    CCDS22011.1
    UniProtKB/Swiss-Prot
    Q52KM4, Q93092
    Related
    ENSMUSP00000026576.5, ENSMUST00000026576.5
    Conserved Domains (2) summary
    PRK05269
    Location:11329
    PRK05269; transaldolase B; Provisional
    PTZ00411
    Location:11330
    PTZ00411; transaldolase-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140972073..140982889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)