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TAL2 TAL bHLH transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 6887, updated on 5-Aug-2022

Summary

Official Symbol
TAL2provided by HGNC
Official Full Name
TAL bHLH transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:11557
See related
Ensembl:ENSG00000186051 MIM:186855; AllianceGenome:HGNC:11557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]
Orthologs
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Genomic context

See TAL2 in Genome Data Viewer
Location:
9q31.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (105662457..105663124)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (117837138..117837805)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (108424738..108425405)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FKTN antisense RNA 1 Neighboring gene fukutin Neighboring gene GATA motif-containing MPRA enhancer 228 Neighboring gene uncharacterized LOC107987107 Neighboring gene serine and arginine rich splicing factor 10 pseudogene Neighboring gene transmembrane protein 38B Neighboring gene Sharpr-MPRA regulatory region 1451

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Acute lymphoid leukemia
MedGen: C0023449 OMIM: 613065 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in thalamus development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
T-cell acute lymphocytic leukemia protein 2
Names
T-cell acute lymphocytic leukemia 2
TAL-2
class A basic helix-loop-helix protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005421.3NP_005412.1  T-cell acute lymphocytic leukemia protein 2

    See identical proteins and their annotated locations for NP_005412.1

    Status: REVIEWED

    Source sequence(s)
    AA767775, AL158070, BC126373
    Consensus CDS
    CCDS6767.1
    UniProtKB/Swiss-Prot
    A0AVI7, Q16559
    Related
    ENSP00000334547.3, ENST00000334077.6
    Conserved Domains (1) summary
    cd19707
    Location:262
    bHLH_TS_TAL2; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    105662457..105663124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    117837138..117837805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)