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Tal2 T cell acute lymphocytic leukemia 2 [ Mus musculus (house mouse) ]

Gene ID: 21350, updated on 24-Jan-2023

Summary

Official Symbol
Tal2provided by MGI
Official Full Name
T cell acute lymphocytic leukemia 2provided by MGI
Primary source
MGI:MGI:99540
See related
Ensembl:ENSMUSG00000028417 AllianceGenome:MGI:99540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bHLHa19
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within midbrain development; post-embryonic development; and thalamus development. Is expressed in several structures, including central nervous system; future midbrain; and genitourinary system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia. Orthologous to human TAL2 (TAL bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 16.8), CNS E14 (RPKM 5.3) and 1 other tissue See more
Orthologs
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Genomic context

See Tal2 in Genome Data Viewer
Location:
4 B2; 4 28.75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (53779701..53788712)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (53779701..53788712)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III and SPRY domain containing 1-like Neighboring gene single stranded DNA binding protein 4 pseudogene Neighboring gene fukutin Neighboring gene ribosomal protein S15A, pseudogene 8 Neighboring gene transmembrane protein 38B Neighboring gene nuclear encoded rRNA 5S 185

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130117

General protein information

Preferred Names
T-cell acute lymphocytic leukemia protein 2 homolog
Names
TAL-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009317.4NP_033343.1  T-cell acute lymphocytic leukemia protein 2 homolog

    See identical proteins and their annotated locations for NP_033343.1

    Status: VALIDATED

    Source sequence(s)
    AL844585
    Consensus CDS
    CCDS18192.1
    UniProtKB/Swiss-Prot
    Q62282
    UniProtKB/TrEMBL
    Q2TB09
    Related
    ENSMUSP00000030124.4, ENSMUST00000030124.4
    Conserved Domains (1) summary
    smart00353
    Location:860
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    53779701..53788712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)