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Pih1d1 PIH1 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68845, updated on 26-Sep-2022

Summary

Official Symbol
Pih1d1provided by MGI
Official Full Name
PIH1 domain containing 1provided by MGI
Primary source
MGI:MGI:1916095
See related
Ensembl:ENSMUSG00000003423 AllianceGenome:MGI:1916095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nop17; 1110061L23Rik; 4933413A04Rik
Summary
Predicted to enable several functions, including RNA polymerase I core promoter sequence-specific DNA binding activity; enzyme binding activity; and phosphoprotein binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; positive regulation of signal transduction; and regulation of cellular protein metabolic process. Located in nucleus. Orthologous to human PIH1D1 (PIH1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 78.1), CNS E11.5 (RPKM 23.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pih1d1 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44800036..44809489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45150613..45160065)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13A Neighboring gene small nucleolar RNA, C/D box 32A Neighboring gene FMS-like tyrosine kinase 3 ligand Neighboring gene aldehyde dehydrogenase 16 family, member A1 Neighboring gene solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 Neighboring gene microRNA 7055 Neighboring gene golgi-associated olfactory signaling regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TORC1 complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in box C/D snoRNP assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone H3-K9 dimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone H3-K9 trimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H3-K9 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in snoRNA localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of R2TP complex ISO
Inferred from Sequence Orthology
more info
 
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of pre-snoRNP complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PIH1 domain-containing protein 1
Names
nucleolar protein 17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278207.1NP_001265136.1  PIH1 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001265136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK004341
    Consensus CDS
    CCDS21232.1
    UniProtKB/Swiss-Prot
    Q6NV90, Q9CQJ2
    Related
    ENSMUSP00000148186.2, ENSMUST00000210139.2
    Conserved Domains (2) summary
    pfam18201
    Location:215286
    PIH1_CS; PIH1 CS-like domain
    cl00175
    Location:33180
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. NM_001285904.2NP_001272833.1  PIH1 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001272833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC149868, BC068254
    Consensus CDS
    CCDS21232.1
    UniProtKB/Swiss-Prot
    Q6NV90, Q9CQJ2
    Related
    ENSMUSP00000103441.2, ENSMUST00000107811.4
    Conserved Domains (2) summary
    pfam18201
    Location:215286
    PIH1_CS; PIH1 CS-like domain
    cl00175
    Location:33180
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  3. NM_029406.4NP_083682.1  PIH1 domain-containing protein 1

    See identical proteins and their annotated locations for NP_083682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK004341, AK146039
    Consensus CDS
    CCDS21232.1
    UniProtKB/Swiss-Prot
    Q6NV90, Q9CQJ2
    Related
    ENSMUSP00000082490.6, ENSMUST00000085375.13
    Conserved Domains (2) summary
    pfam18201
    Location:215286
    PIH1_CS; PIH1 CS-like domain
    cl00175
    Location:33180
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44800036..44809489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541156.2XP_006541219.1  PIH1 domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006541219.1

    UniProtKB/Swiss-Prot
    Q6NV90, Q9CQJ2
    Conserved Domains (2) summary
    pfam18201
    Location:215286
    PIH1_CS; PIH1 CS-like domain
    cl00175
    Location:33180
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. XM_036153406.1XP_036009299.1  PIH1 domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6NV90
    Conserved Domains (2) summary
    pfam18201
    Location:215286
    PIH1_CS; PIH1 CS-like domain
    cl00175
    Location:33180
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RNA

  1. XR_003946555.2 RNA Sequence

  2. XR_003946556.2 RNA Sequence