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PIH1D1 PIH1 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 55011, updated on 24-Nov-2020

Summary

Official Symbol
PIH1D1provided by HGNC
Official Full Name
PIH1 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26075
See related
Ensembl:ENSG00000104872 MIM:611480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pih1; MOT48; NOP17
Expression
Ubiquitous expression in placenta (RPKM 13.7), lymph node (RPKM 13.6) and 25 other tissues See more
Orthologs

Genomic context

See PIH1D1 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49446298..49452392, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49949550..49955266, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene golgi associated olfactory signaling regulator Neighboring gene solute carrier family 17 member 7 Neighboring gene aldehyde dehydrogenase 16 family member A1 Neighboring gene fms related receptor tyrosine kinase 3 ligand

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT RNA polymerase I cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase I core promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase I preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box C/D snoRNP assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
establishment of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H3-K9 dimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H3-K9 trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H4-K16 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of histone H3-K4 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
snoRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
R2TP complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pre-snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PIH1 domain-containing protein 1
Names
nucleolar protein 17 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017916.3NP_060386.1  PIH1 domain-containing protein 1

    See identical proteins and their annotated locations for NP_060386.1

    Status: VALIDATED

    Source sequence(s)
    AA018444, AK000650, DC385084
    Consensus CDS
    CCDS12765.1
    UniProtKB/Swiss-Prot
    Q9NWS0
    Related
    ENSP00000262265.4, ENST00000262265.10
    Conserved Domains (1) summary
    cl00175
    Location:30284
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49446298..49452392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451568.1XP_024307336.1  PIH1 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cl00175
    Location:1196
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. XM_024451570.1XP_024307338.1  PIH1 domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl00175
    Location:6157
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  3. XM_024451569.1XP_024307337.1  PIH1 domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl00175
    Location:6157
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RNA

  1. XR_430203.3 RNA Sequence

  2. XR_430202.4 RNA Sequence

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